ArticleThe Indian journal of medical research2012
Evaluation of antimicrobial activity of certain combinations of antibiotics against in vitro Staphylococcus epidermidis biofilms.
Article in The Indian journal of medical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
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- Antimicrobial Performance of a Novel Drug-Eluting Bioenvelope.Antibiotics (Basel, Switzerland) · 2025Article
- Antibiotic-Eluting Envelopes for the Prevention of Cardiac Implantable Electronic Device Infections: Rationale, Efficacy, and Cost-Effectiveness.Frontiers in cardiovascular medicine · 2022Review
- Attenuation of Aggregatibacter actinomycetemcomitans virulence using curcumin-decorated nanophytosomes-mediated photo-sonoantimicrobial chemotherapy.Scientific reports · 2021Article
- Antibiotic-Eluting Envelopes to Prevent Cardiac-Implantable Electronic Device Infection: Past, Present, and Future.Cureus · 2021Review
- Article
- Development of an Inverted Epifluorescence Microscope for Long-Term Monitoring of Bacteria in Multiplexed Microfluidic Devices.Sensors (Basel, Switzerland) · 2020Article
- The Antibacterial Effect of Silver Nanoparticles on Staphylococcus epidermidis Strains with Different Biofilm-Forming Ability.Nanomaterials (Basel, Switzerland) · 2020Article
- Osmotic Compounds Enhance Antibiotic Efficacy against Acinetobacter baumannii Biofilm Communities.Applied and environmental microbiology · 2017Article
- Dose-Dependent Effects of Common Antibiotics Used to TreatIranian journal of pathology · 2017Article
- Rifamycins, Alone and in Combination.Cold Spring Harbor perspectives in medicine · 2016Review
- Cinnamon Oil and Chitosan Coating on Orthopaedic Implant Surface for Prevention of Staphylococcus Epidermidis Biofilm Formation.Malaysian orthopaedic journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesStaphylococcus epidermidis is the most common pathogen associated with infections of surgical implants and other prosthetic devices owing to its adhesion and biofilm-forming ability on biomaterials surfaces. The objective of this study was to compare susceptibilities of biofilm-grown cells to single antibiotic and in combination with others to identify those that were effective against S. epidermidis biofilms.
methodsBiofilms were grown in the MBEC™ assay system. The use of this methodology allowed a rapid testing of an array of antibiotics alone (eight) and in combination (25 double combinations). The antibacterial effect of all treatments tested was determined by colony forming units (cfu) enumeration method.
resultsThe MBEC™ assay system produced multiple and reproducible biofilms of S. epidermidis. Although none of the antibiotics tested have demonstrated an antimicrobial effect (log reduction >3) against all S. epidermidis isolates biofilms, but combinations containing rifampicin showed in general a broader spectrum namely rifampicin-gentamicin and rifampicin-clindamycin. Levofloxacin in combination with rifampicin showed a killing effect against three isolates but failed to attain a bactericidal action against the other two. INTERPRETATION &
conclusionsOur findings showed that rifampicin should be a part of any antibiotic therapy directed against S. epidermidis biofilms. However, the efficient antibiotics combination might be dependent on S. epidermidis isolate being tested.
Indexed as
Identifiers
22664505PMC3385241W2116999183What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.