Evidence map›Paper›PMID 22664276›Full record

ReviewCurrent opinion in microbiology2012

Entamoeba histolytica: a snapshot of current research and methods for genetic analysis.

Laura Morf, Upinder Singh

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Antiamoebic drugs for treating amoebic colitis.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Article
  3. First Molecular Identification ofVeterinary sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Membranes · 2021
    Article
  8. Article
  9. How to manage: liver abscess.Frontline gastroenterology · 2021
    Article
  10. Unusual case of severe colitis.Frontline gastroenterology · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura MorfDivision of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Upinder Singh

Funding

Investigating Entamoeba histolytica Colonic PathogenesisR01AI053724 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2003 to 2012
$3.8M
Identification of Entamoeba small RNAs by pyrosequencingR21AI085178 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2010 to 2011
$438k
NIAID NIH HHS R01 AI053724NIAID NIH HHS R21 AI085178
6 · The paper itself

Abstract

Entamoeba histolytica represents one of the leading causes of parasitic death worldwide. Although identified as the causative agent of amebiasis since 1875, the molecular mechanisms by which the parasite causes disease are still not fully understood. Studying Entamoeba reveals insights into a eukaryotic cell that differs in many ways from better-studied model organisms. Thus, much can be learned from this protozoan parasite on evolution, cell biology, and RNA biology. In this review we discuss selected research highlights in Entamoeba research and focus on the development of molecular biological techniques to study this pathogen. We end by highlighting some of the many questions that remain to be answered in order to fully understand this important human pathogen.

Indexed as

Entamoeba histolyticaEntamoebiasisHost-Parasite InteractionsHumansProtozoan ProteinsRNA InterferenceVirulence FactorsProtozoan ProteinsVirulence Factors

Identifiers

PMID22664276
PMCPMC3424301

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.