ReviewRespiratory care2012
Persistent systemic inflammation in chronic critical illness.
Review in Respiratory care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Harness machine learning for multiple prognoses prediction in sepsis patients: evidence from the MIMIC-IV database.BMC medical informatics and decision making · 2025Article
- Novel opportunities for treating complex neuropsychiatric and neurocognitive conditions based on recent developments with xanomeline.Frontiers in psychiatry · 2025Article
- Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients.Annals of geriatric medicine and research · 2024Article
- Combining proteins with n-3 PUFAs (EPA + DHA) and their inflammation pro-resolution mediators for preservation of skeletal muscle mass.Critical care (London, England) · 2024Review
- A multiscale inflammatory map: linking individual stress to societal dysfunction.Frontiers in science · 2024Article
- Exercise Limitation after Critical Versus Mild COVID-19 Infection: A Metabolic Perspective.Journal of clinical medicine · 2022Article
- Haemoglobin value and red blood cell transfusions in prolonged weaning from mechanical ventilation: a retrospective observational study.BMJ open respiratory research · 2022Observational
- Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects.American journal of translational research · 2022Article
- Assessing calorie and protein recommendations for survivors of critical illness weaning from prolonged mechanical ventilation - can we find a proper balance?Clinical nutrition ESPEN · 2021Article
- Cardiopulmonary Exercise Testing in Critically Ill Coronavirus Disease 2019 Survivors: Evidence of a Sustained Exercise Intolerance and Hypermetabolism.Critical care explorations · 2021Article
- Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients.Metabolites · 2021Article
- The relationship between the degree of malnutrition and changes in selected parameters of the immune response in critically ill patients.Central-European journal of immunology · 2021Article
- Hi-C Metagenomics in the ICU: Exploring Clinically Relevant Features of Gut Microbiome in Chronically Critically Ill Patients.Frontiers in microbiology · 2021Article
- The Effect of Aging Physiology on Critical Care.Critical care clinics · 2021Review
- Outcome Predictive Value of Serum Ferritin in ICU Patients with Long ICU Stay.Medicina (Kaunas, Lithuania) · 2020Article
- Nutrition and the gut microbiome during critical illness: A new insight of nutritional therapy.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2020Review
- Circadian Disruption in Critical Illness.Frontiers in neurology · 2020Review
- Mortality, morbidity, and quality-of-life outcomes of patients requiring ≥ 14 days of mechanical ventilation: a 12-month post-intensive-care-unit cohort study.Revista Brasileira de terapia intensiva · 2019Article
- Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway.Frontiers in psychiatry · 2019Article
- The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.Critical care medicine · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Chronic critical illness (CCI) is syndrome of neuromuscular weakness, brain dysfunction, malnutrition, endocrinopathies, and symptom distress. Two conceptual themes may be useful in discussing CCI. The first is a clinical roadmap in which a patient suffers an acute critical illness, survives the initial insult, but yet is unable to be liberated from the ventilator. The second framework considers the effect of systemic inflammation and CCI, linking acute CCI risk factors with the common clinical features of CCI. Given the association between common CCI antecedents and inflammation, attempts to control and balance the pro-inflammatory and anti-inflammatory mediators should begin as early as possible and continue throughout the ICU stay. Since surrogate measures such as biomarkers often fail to predict the effect of interventions, the focus should be on the outcomes patients experience. As of now, providing evidence-based, high quality ICU management of patients at risk for CCI appears to be the best strategy of care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.