ArticleJournal of the American Chemical Society2012
Color vision: "OH-site" rule for seeing red and green.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Turning Red to Green Repeatedly: Ancestral LWS Duplications Drive Convergent Visual Tuning in Teleost Fishes.Molecular ecology · 2026Article
- Spectral Tuning in Mammalian Melanopsins.Molecular biology and evolution · 2025Article
- Trichromacy and ultraviolet vision in a nocturnal marsupial.Scientific reports · 2025Article
- Schiff base deprotonation and structural changes in a mouse UV-sensitive cone visual pigment revealed by FTIR spectroscopy at 77 K.Biophysics and physicobiology · 2025Article
- Glu102Biochemistry · 2024Article
- High-performance flower-like and biocompatible nickel-coated FeNanoscale advances · 2023Article
- Jewel Beetle Opsin Duplication and Divergence Is the Mechanism for Diverse Spectral Sensitivities.Molecular biology and evolution · 2023Article
- The evolutionary history and spectral tuning of vertebrate visual opsins.Developmental biology · 2023Review
- Evolutionary history limits species' ability to match colour sensitivity to available habitat light.Proceedings. Biological sciences · 2022Article
- Vitamin ADevelopmental biology · 2021Review
- Article
- Light-induced difference FTIR spectroscopy of primate blue-sensitive visual pigment at 163 K.Biophysics and physicobiology · 2021Article
- Convergent spectral shifts to blue-green vision in mammals extends the known sensitivity of vertebrate M/LWS pigments.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The retinal pigments of the whale shark (Visual neuroscience · 2019Article
- Adaptive Landscapes in the Age of Synthetic Biology.Molecular biology and evolution · 2019Review
- Red-shifting mutation of light-driven sodium-pump rhodopsin.Nature communications · 2019Article
- Spectral Tuning Mechanism of Primate Blue-sensitive Visual Pigment Elucidated by FTIR Spectroscopy.Scientific reports · 2017Article
- Advances in understanding the molecular basis of the first steps in color vision.Progress in retinal and eye research · 2015Review
- Unusual kinetics of thermal decay of dim-light photoreceptors in vertebrate vision.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Eyes gather information, and color forms an extremely important component of the information, more so in the case of animals to forage and navigate within their immediate environment. By using the ONIOM (QM/MM) (ONIOM = our own N-layer integrated molecular orbital plus molecular mechanics) method, we report a comprehensive theoretical analysis of the structure and molecular mechanism of spectral tuning of monkey red- and green-sensitive visual pigments. We show that interaction of retinal with three hydroxyl-bearing amino acids near the β-ionone ring part of the retinal in opsin, A164S, F261Y, and A269T, increases the electron delocalization, decreases the bond length alternation, and leads to variation in the wavelength of maximal absorbance of the retinal in the red- and green-sensitive visual pigments. On the basis of the analysis, we propose the "OH-site" rule for seeing red and green. This rule is also shown to account for the spectral shifts obtained from hydroxyl-bearing amino acids near the Schiff base in different visual pigments: at site 292 (A292S, A292Y, and A292T) in bovine and at site 111 (Y111) in squid opsins. Therefore, the OH-site rule is shown to be site-specific and not pigment-specific and thus can be used for tracking spectral shifts in any visual pigment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.