Evidence map›Paper›PMID 22662320›Full record

ArticleFrontiers in oncology2012

The first European interdisciplinary ewing sarcoma research summit.

Heinrich Kovar, Javier Alonso, Pierre Aman, Dave N T Aryee, Jozef Ban, Sue A Burchill, Stefan Burdach, Enrique De Alava, Olivier Delattre, Uta Dirksen and 27 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Does PAX7 and NKX2.2 immunoreactivity in Ewing sarcoma have prognostic significance?Virchows Archiv : an international journal of pathology · 2022
    Article
  5. Article
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  8. Review
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  17. Molecular mechanisms of ETS transcription factor-mediated tumorigenesis.Critical reviews in biochemistry and molecular biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 12 countries.

Heinrich KovarChildren's Cancer Research Institute, St. Anna Kinderkrebsforschung Vienna, Austria.
Javier Alonso
Pierre Aman
Dave N T Aryee
Jozef Ban
Sue A Burchill
Stefan Burdach
Enrique De Alava
Olivier Delattre
Uta Dirksen
Argyro Fourtouna
Simone Fulda
Lee J Helman
David Herrero-Martin
Pancras C W Hogendoorn
Udo Kontny
Elizabeth R Lawlor
Stephen L Lessnick
Antonio Llombart-Bosch
Markus Metzler
Richard Moriggl
Stephan Niedan
Jenny Potratz
Françoise Redini
Günther H S Richter
Lucia T Riedmann
Claudia Rossig
Beat W Schäfer
Raphaela Schwentner
Katia Scotlandi
Poul H Sorensen
Martin S Staege
Franck Tirode
Jeffrey Toretsky
Selena Ventura
Angelika Eggert
Ruth Ladenstein
Cancer Research Institute of the Slovak Academy of Sciences · SKChildren’s Minnesota - St. Paul Hospital · USInserm · FRKlinikum rechts der Isar · DESt. Anna Children's Cancer Research InstituteUniversity of Zurich · CHCentro de Investigación del Cáncer · ESCentro Nacional de Microbiologia · ESEssen University Hospital · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGeorgetown University Medical Center · USGoethe University Frankfurt · DEHuntsman Cancer Institute · USInstitut Curie · FRInstitute of Molecular Medicine · INIstituto Ortopedico Rizzoli · ITLeiden University Medical Center · NLLudwig Boltzmann Institute for Cancer Research · ATMartin Luther University Halle-Wittenberg · DENational Institutes of Health · US

Funding

Molecular Biology of Pediatric TumorsZIASC006892 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI HELMAN, LEE J. · 2009 to 2017
$6.3M
Solid TumorsZIASC006891 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI HELMAN, LEE J. · 2009 to 2017
$5.0M
6 · The paper itself

Abstract

The European Network for Cancer Research in Children and Adolescents (ENCCA) provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA objectives is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options, since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma (ES), where long term survival rates are still below 20%. Despite significant progress in our understanding of ES biology, clinical translation of promising laboratory results has not yet taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and five North American opinion leaders in December 2011 to exchange thoughts and discuss the state of the art in ES research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.

Indexed as

animal modelsbiomarkersdrug screenepigeneticsEwing sarcomagenomicsprognosissarcomagenesis

Identifiers

PMID22662320
PMCPMC3361960
OpenAlexW2144231724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.