ArticlePloS one2012
Internal ribosomal entry site-mediated translation is important for rhythmic PERIOD1 expression.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- SYNCRIP drives ferroptosis resistance and metabolic activation via SIRT1 and HK2 in glioblastoma.International journal of biological sciences · 2026Article
- Rhythmic Dynamics of Stress Granules inInternational journal of molecular sciences · 2025Article
- Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase.Journal of lipid research · 2023Article
- Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank.Research square · 2023Article
- Internal ribosomal entry site-mediated translational activity of nitric oxide synthase 2.Animal cells and systems · 2023Article
- Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver.PLoS genetics · 2022Article
- PTBP1 Positively Regulates the Translation of Circadian Clock Gene,International journal of molecular sciences · 2020Article
- New insights into non-transcriptional regulation of mammalian core clock proteins.Journal of cell science · 2020Review
- Circadian Posttranscriptional Regulatory Mechanisms in Mammals.Cold Spring Harbor perspectives in biology · 2018Review
- Post-transcriptional control of the mammalian circadian clock: implications for health and disease.Pflugers Archiv : European journal of physiology · 2016Review
- Effects of different per translational kinetics on the dynamics of a core circadian clock model.PloS one · 2015Article
- AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.Nucleic acids research · 2014Article
- MicroRNA-185 oscillation controls circadian amplitude of mouse Cryptochrome 1 via translational regulation.Molecular biology of the cell · 2013Article
- Insert sequence length determines transfection efficiency and gene expression levels in bicistronic mammalian expression vectors.International journal of biochemistry and molecular biology · 2013Article
- NAT1/DAP5/p97 and atypical translational control in the Drosophila Circadian Oscillator.Genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse PERIOD1 (mPER1) plays an important role in the maintenance of circadian rhythm. Translation of mPer1 is directed by both a cap-dependent process and cap-independent translation mediated by an internal ribosomal entry site (IRES) in the 5' untranslated region (UTR). Here, we compared mPer1 IRES activity with other cellular IRESs. We also found critical region in mPer1 5'UTR for heterogeneous nuclear ribonucleoprotein Q (HNRNPQ) binding. Deletion of HNRNPQ binding region markedly decreased IRES activity and disrupted rhythmicity. A mathematical model also suggests that rhythmic IRES-dependent translation is a key process in mPER1 oscillation. The IRES-mediated translation of mPer1 will help define the post-transcriptional regulation of the core clock genes.
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