ArticlePloS one2012
Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Review of the aetiologies of central nervous system infections in Vietnam.Frontiers in public health · 2024Pooled it
- Pooled it
- Streptococcus suis Meningitis: A Systematic Review and Meta-analysis.PLoS neglected tropical diseases · 2015Pooled it
- Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.Future microbiologyPooled it
- Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship.The Journal of infectious diseases · 2025Article
- A multifaceted intervention to improve diagnosis and early management of hospitalised patients with suspected acute brain infections in Brazil, India, and Malawi: an international multicentre intervention study.Lancet (London, England) · 2025Observational
- Epidemiology of pneumococcal meningitis in sentinel hospital surveillance of Viet Nam, 2015-2018.BMC infectious diseases · 2024Article
- Clinical presentation, management, and outcome of suspected central nervous system infections in Indonesia: a prospective cohort study.Infection · 2024Article
- Central nervous system infection in a pediatric population in West Java.PLoS neglected tropical diseases · 2023Article
- Shared and unique antibody and B cell profiles in HIV-positive and HIV-negative individuals with cryptococcal meningoencephalitis.Medical mycology · 2023Article
- Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019.Virology journal · 2023Article
- Childhood Bacterial Meningitis Surveillance in Southern Vietnam: Trends and Vaccination Implications From 2012 to 2021.Open forum infectious diseases · 2023Article
- The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.BMC infectious diseases · 2023Article
- Epidemiological and clinical characteristics of central nervous system infections in a tertiary center: A retrospective study.Health science reports · 2023Article
- Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam.EcoHealth · 2022Article
- Outbreak of central nervous system infections among children in Thai Binh, Viet Nam.Emerging microbes & infections · 2022Article
- Aetiologies and clinical presentation of central nervous system infections in Vietnamese patients: a prospective study.Scientific reports · 2022Article
- Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study.The Lancet. Global health · 2022Observational
- Metagenomic next-generation sequencing of cell-free and whole-cell DNA in diagnosing central nervous system infections.Frontiers in cellular and infection microbiology · 2022Article
- Main Clinical and Laboratory Features of Children with Bacterial Meningitis: Experience from a Tertiary Paediatric Centre in Central Vietnam.Pediatric health, medicine and therapeutics · 2022Article
Corrections and comments
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Authors and funding
29 authors at 12 institutions in 4 countries.
Funding
Abstract
backgroundInfectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen.
methodsWe conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007-April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology.
resultsWe recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children.
conclusionsZoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.
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