ArticlePloS one2012
Gas7-deficient mouse reveals roles in motor function and muscle fiber composition during aging.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- NMJ-related diseases beyond the congenital myasthenic syndromes.Frontiers in cell and developmental biology · 2023Review
- Detection and Visualization of Heterozygosity-Rich Regions and Runs of Homozygosity in Worldwide Sheep Populations.Animals : an open access journal from MDPI · 2021Article
- A Functional SNP in the Promoter ofFrontiers in cell and developmental biology · 2021Article
- SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells.BMC genomics · 2020Article
- Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons.FASEB bioAdvances · 2020Article
- Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.Molecular brain · 2016Article
- DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.Investigative ophthalmology & visual science · 2014Article
- Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.BioMed research international · 2014Article
- Gas7 is required for mesenchymal stem cell-derived bone development.Stem cells international · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowth arrest-specific gene 7 (Gas7) has previously been shown to be involved in neurite outgrowth in vitro; however, its actual role has yet to be determined. To investigate the physiological function of Gas7 in vivo, here we generated a Gas7-deficient mouse strain with a labile Gas7 mutant protein whose functions are similar to wild-type Gas7. METHODOLOGY/PRINCIPAL
findingsOur data show that aged Gas7-deficient mice have motor activity defects due to decreases in the number of spinal motor neurons and in muscle strength, of which the latter may be caused by changes in muscle fiber composition as shown in the soleus. In cross sections of the soleus of Gas7-deficient mice, gross morphological features and levels of myosin heavy chain I (MHC I) and MHC II markers revealed significantly fewer fast fibers. In addition, we found that nerve terminal sprouting, which may be associated with slow and fast muscle fiber composition, was considerably reduced at neuromuscular junctions (NMJ) during aging. CONCLUSIONS/SIGNIFICANCE: These findings indicate that Gas7 is involved in motor neuron function associated with muscle strength maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.