ArticlePloS one2012
Systematic deletion of homeobox genes in Podospora anserina uncovers their roles in shaping the fruiting body.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Homeobox transcription factor BmHox7 is required for sexual reproduction, but not for appressorial development and pathogenicity inMycoscience · 2025Article
- Identification of Homeobox Transcription Factors in a Dimorphic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Regulatory functions of homeobox domain transcription factors in fungi.Applied and environmental microbiology · 2024Review
- Mutations inJournal of fungi (Basel, Switzerland) · 2024Article
- Transcription factors: switches for regulating growth and development in macrofungi.Applied microbiology and biotechnology · 2023Review
- Stepwise recombination suppression around the mating-type locus in an ascomycete fungus with self-fertile spores.PLoS genetics · 2023Article
- Homeobox transcription factor HbxA influences expression of over one thousand genes in the model fungus Aspergillus nidulans.PloS one · 2023Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
- Recombination suppression and evolutionary strata around mating-type loci in fungi: documenting patterns and understanding evolutionary and mechanistic causes.The New phytologist · 2021Review
- Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans.Scientific reports · 2020Article
- A Homeobox Transcription Factor UvHOX2 Regulates Chlamydospore Formation, Conidiogenesis, and Pathogenicity inFrontiers in microbiology · 2019Article
- Article
- The Aspergillus flavus Homeobox Gene, hbx1, is Required for Development and Aflatoxin Production.Toxins · 2017Article
- Transcription factors of Schizophyllum commune involved in mushroom formation and modulation of vegetative growth.Scientific reports · 2017Article
- New insights from an old mutant: SPADIX4 governs fruiting body development but not hyphal fusion in Sordaria macrospora.Molecular genetics and genomics : MGG · 2017Article
- Article
- Gene expression differences among three Neurospora species reveal genes required for sexual reproduction in Neurospora crassa.PloS one · 2014Article
- A network of HMG-box transcription factors regulates sexual cycle in the fungus Podospora anserina.PLoS genetics · 2013Article
- A conserved homeobox transcription factor Htf1 is required for phialide development and conidiogenesis in Fusarium species.PloS one · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher fungi, which comprise ascomycetes and basidiomycetes, play major roles in the biosphere. Their evolutionary success may be due to the extended dikaryotic stage of their life cycle, which is the basis for their scientific name: the Dikarya. Dikaryosis is maintained by similar structures, the clamp in basidiomycetes and the crozier in ascomycetes. Homeodomain transcription factors are required for clamp formation in all basidiomycetes studied. We identified all the homeobox genes in the filamentous ascomycete fungus Podospora anserina and constructed deletion mutants for each of these genes and for a number of gene combinations. Croziers developed normally in these mutants, including those with up to six deleted homeogenes. However, some mutants had defects in maturation of the fruiting body, an effect that could be rescued by providing wild-type maternal hyphae. Analysis of mutants deficient in multiple homeogenes revealed interactions between the genes, suggesting that they operate as a complex network. Similar to their role in animals and plants, homeodomain transcription factors in ascomycetes are involved in shaping multicellular structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.