ArticlePloS one2012
A stochastic description of Dictyostelium chemotaxis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
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- Data-driven classification of individual cells by their non-Markovian motion.Biophysical journal · 2024Article
- Nonlinear Growth Dynamics of Neuronal Cells Cultured on Directional Surfaces.Biomimetics (Basel, Switzerland) · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Methods and computational tools to study eukaryotic cell migrationFrontiers in cell and developmental biology · 2024Review
- Biased Random Walk Model of Neuronal Dynamics on Substrates with Periodic Geometrical Patterns.Biomimetics (Basel, Switzerland) · 2023Article
- The aerotaxis ofFrontiers in cell and developmental biology · 2023Article
- Understanding the Cell's Response to Chemical Signals: Utilisation of Microfluidic Technology in Studies of Cellular andMicromachines · 2022Review
- Anomalous diffusion and asymmetric tempering memory in neutrophil chemotaxis.PLoS computational biology · 2022Article
- Feedback-controlled dynamics of neuronal cells on directional surfaces.Biophysical journal · 2022Article
- Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments.iScience · 2021Article
- Neuronal Growth and Formation of Neuron Networks on Directional Surfaces.Biomimetics (Basel, Switzerland) · 2021Article
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- Cellular velocity, electrical persistence and sensing in developed and vegetative cells during electrotaxis.PloS one · 2020Article
- Stochastic and Heterogeneous Cancer Cell Migration: Experiment and Theory.Scientific reports · 2019Article
- Harnessing Motile Amoeboid Cells as Trucks for Microtransport and -Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
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- Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells.Nature communications · 2018Article
- Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemotaxis, the directed motion of a cell toward a chemical source, plays a key role in many essential biological processes. Here, we derive a statistical model that quantitatively describes the chemotactic motion of eukaryotic cells in a chemical gradient. Our model is based on observations of the chemotactic motion of the social ameba Dictyostelium discoideum, a model organism for eukaryotic chemotaxis. A large number of cell trajectories in stationary, linear chemoattractant gradients is measured, using microfluidic tools in combination with automated cell tracking. We describe the directional motion as the interplay between deterministic and stochastic contributions based on a Langevin equation. The functional form of this equation is directly extracted from experimental data by angle-resolved conditional averages. It contains quadratic deterministic damping and multiplicative noise. In the presence of an external gradient, the deterministic part shows a clear angular dependence that takes the form of a force pointing in gradient direction. With increasing gradient steepness, this force passes through a maximum that coincides with maxima in both speed and directionality of the cells. The stochastic part, on the other hand, does not depend on the orientation of the directional cue and remains independent of the gradient magnitude. Numerical simulations of our probabilistic model yield quantitative agreement with the experimental distribution functions. Thus our model captures well the dynamics of chemotactic cells and can serve to quantify differences and similarities of different chemotactic eukaryotes. Finally, on the basis of our model, we can characterize the heterogeneity within a population of chemotactic cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.