ArticleArchives of medical science : AMS2012
Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old.
Article in Archives of medical science : AMS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Activation of the Monocyte/Macrophage System and Abnormal Blood Levels of Lymphocyte Subpopulations in Individuals with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- In search of immune cellular sources of abnormal cytokines in the blood in autism spectrum disorder: A systematic review of case-control studies.Frontiers in immunology · 2022Pooled it
- Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis.Molecular autism · 2021Pooled it
- Gut microbiota metabolites, secretory immunoglobulin A and Bayley-III cognitive scores in children from the CHILD Cohort Study.Brain, behavior, & immunity - health · 2025Article
- Review
- Effects of COVID-19 on children with autism.World journal of virology · 2022Review
- Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?International journal of molecular sciences · 2022Review
- Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum.Gut · 2022Article
- A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the Therapeutic Use of Intravenous Immunoglobulins (IVIG) in Autism Spectrum Disorder.Journal of personalized medicine · 2021Review
- The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders.Frontiers in psychiatry · 2021Article
- Transcriptome signatures from discordant sibling pairs reveal changes in peripheral blood immune cell composition in Autism Spectrum Disorder.Translational psychiatry · 2020Article
- Changing conceptualizations of regression: What prospective studies reveal about the onset of autism spectrum disorder.Neuroscience and biobehavioral reviews · 2019Review
- Immune Abnormalities in Autism Spectrum Disorder-Could They Hold Promise for Causative Treatment?Molecular neurobiology · 2018Review
- Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2018Review
- Gastrointestinal symptoms and autism spectrum disorder: links and risks - a possible new overlap syndrome.Pediatric health, medicine and therapeutics · 2015Review
- Corticosteroid therapy in regressive autism: Preliminary findings from a retrospective study.BMC medicine · 2014Article
- Antibodies against food antigens in patients with autistic spectrum disorders.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionImmune system dysfunction is considered to be one of many medical disorders found in children with autism. The primary objective of the study was to assess if blood tests reflecting humoral immunity (IgA, IgG, IgM, IgE) are useful in identifying children with regressive autism. The secondary objective was to evaluate a part of the cellular arm of immunity (CD4/CD25 Tregs, CD4/CD23 cells) in those children. MATERIAL AND
methodsUsing a clinical case-control design, the systemic levels of immunoglobulins and lymphocyte subpopulations analysed by flow cytometry were compared in children aged 3-6 years old with a new diagnosis of regressive autism (n = 24; mean age: 4.25 ±1.70 years; male 23/24) and in sex- and age-matched healthy children (n = 24; aged 4.25 ±2.20 years; male 23/24).
resultsThe humoral immunity profile, described by three binary variables, IgA < 0.97 g/l, IgE > 36 IU/ml, and IgG > 6.3 g/l, with a sensitivity of 79% and a specificity of 83% (p < 0.0001), was able to identify children with autism. The highest risk of autism diagnosis was associated with IgA < 0.97g/l (OR - 23.0; p < 0.001). A higher number of CD19/CD23 was found in children diagnosed with autism than in the control group (36.82 ±6.72% vs. 18.20 ±3.95%; p < 0.02). No correlation between the number of CD23-positive cells and serum IgE levels was observed.
conclusionsA subtle shift of serum immunoglobulins consisting of low-normal IgA and B cell activation expressed by an increase of CD23-positive cells may characterize children with regressive autism aged 3-6 years old.
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