ArticleThe Journal of biological chemistry2012
Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Cells stably expressing shRNA against MYO10 display altered cell motility.microPublication biology · 2025Article
- Hundreds of myosin 10s are pushed to the tips of filopodia and could cause traffic jams on actin.eLife · 2024Article
- Hundreds of myosin 10s are pushed to the tips of filopodia and could cause traffic jams on actin.bioRxiv : the preprint server for biology · 2024Article
- Genomic characteristics of adipose-derived stromal cells induced into neurons based on single-cell RNA sequencing.Heliyon · 2024Article
- Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.Scientific reports · 2024Article
- Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.Molecular biology of the cell · 2024Article
- Heterogeneity in susceptibility to polycystic ovary syndrome among women with epilepsy.Acta epileptologica · 2023Article
- Peering into tunneling nanotubes-The path forward.The EMBO journal · 2021Review
- Article
- Tunneling nanotubes and actin cytoskeleton dynamics in glaucoma.Neural regeneration research · 2020Review
- Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning.Science advances · 2020Article
- Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease.BioMed research international · 2020Review
- Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Phenotypic analysis of Myo10 knockout (Myo10Scientific reports · 2019Article
- Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.Scientific reports · 2018Article
- The emerging role of minor intron splicing in neurological disorders.Cell stress · 2018Review
- Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.Scientific reports · 2017Article
- IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth.Oncotarget · 2017Article
- RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.Nucleic acids research · 2017Article
- Myosin-10 independently influences mitotic spindle structure and mitotic progression.Cytoskeleton (Hoboken, N.J.) · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
Myo10 is an unconventional myosin that localizes to and induces filopodia, structures that are critical for growing axons. In addition to the ~240-kDa full-length Myo10, brain expresses a ~165 kDa isoform that lacks a functional motor domain and is known as headless Myo10. We and others have hypothesized that headless Myo10 acts as an endogenous dominant negative of full-length Myo10, but this hypothesis has not been tested, and the function of headless Myo10 remains unknown. We find that cortical neurons express both headless and full-length Myo10 and report the first isoform-specific localization of Myo10 in brain, which shows enrichment of headless Myo10 in regions of proliferating and migrating cells, including the embryonic ventricular zone and the postnatal rostral migratory stream. We also find that headless and full-length Myo10 are expressed in embryonic and neuronal stem cells. To directly test the function of headless and full-length Myo10, we used RNAi specific to each isoform in mouse cortical neuron cultures. Knockdown of full-length Myo10 reduces axon outgrowth, whereas knockdown of headless Myo10 increases axon outgrowth. To test whether headless Myo10 antagonizes full-length Myo10, we coexpressed both isoforms in COS-7 cells, which revealed that headless Myo10 suppresses the filopodia-inducing activity of full-length Myo10. Together, these results demonstrate that headless Myo10 can function as a negative regulator of full-length Myo10 and that the two isoforms of Myo10 have opposing roles in axon outgrowth.
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