ArticleJournal of bacteriology2012
SrfJ, a Salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Generation of Random lacZY Transcriptional Fusions in the Genome of Salmonella enterica serovar Typhimurium.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Hierarchic regulation of a metabolic pathway: H-NS, CRP, and SsrB controlMicrobiology spectrum · 2024Article
- Speaking the host language: howMicrobiology (Reading, England) · 2023Review
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- Pathogen genomics and phage-based solutions for accurately identifying and controllingFrontiers in microbiology · 2023Article
- Metabolism in the Niche: a Large-Scale Genome-Based Survey Reveals Inositol Utilization To Be Widespread among Soil, Commensal, and Pathogenic Bacteria.Microbiology spectrum · 2022Review
- Downregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity ofVirulence · 2021Article
- Synergistic Effects ofFoods (Basel, Switzerland) · 2021Article
- Article
- The small RNA RssR regulates myo-inositol degradation by Salmonella enterica.Scientific reports · 2018Article
- Small Molecules That Sabotage Bacterial Virulence.Trends in pharmacological sciences · 2017Review
- Heat Survival and Phenotype Microarray Profiling of Salmonella Typhimurium Mutants.Current microbiology · 2017Article
- Dual Expression of theFrontiers in microbiology · 2017Article
- Article
- Comparative Genomics of Pathogenic and Nonpathogenic Strains of Xanthomonas arboricola Unveil Molecular and Evolutionary Events Linked to Pathoadaptation.Frontiers in plant science · 2015Article
- Patterns of expression and translocation of the ubiquitin ligase SlrP in Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2014Article
- DsbA and MgrB regulate steA expression through the two-component system PhoQ/PhoP in Salmonella enterica.Journal of bacteriology · 2013Article
- Article
- Implication of lateral genetic transfer in the emergence of Aeromonas hydrophila isolates of epidemic outbreaks in channel catfish.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virulence-related type III secretion systems are present in many Gram-negative bacterial pathogens. These complex devices translocate proteins, called effectors, from the bacterium into the eukaryotic host cell. Here, we identify the product of srfJ, a Salmonella enterica serovar Typhimurium gene regulated by SsrB, as a new substrate of the type III secretion system encoded by Salmonella pathogenicity island 2. The N-terminal 20-amino-acid segment of SrfJ was recognized as a functional secretion and translocation signal specific for this system. Transcription of srfJ was positively regulated by the PhoP/PhoQ system in an SsrB-dependent manner and was negatively regulated by the Rcs system in an SsrB-independent manner. A screen for regulators of an srfJ-lacZ transcriptional fusion using the T-POP transposon identified IolR, the regulator of genes involved in myo-inositol utilization, as an srfJ repressor. Our results suggest that SrfJ is synthesized both inside the host, in response to intracellular conditions, and outside the host, in myo-inositol-rich environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.