ArticleJournal of muscle research and cell motility1990
Immunoelectron microscopic observations on tropomyosin localization in striated muscle.
Article in Journal of muscle research and cell motility, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Electron microscopy and x-ray diffraction evidence for two Z-band structural states.Biophysical journal · 2011Article
- Vertebrate tropomyosin: distribution, properties and function.Journal of muscle research and cell motility · 2001Review
- Architecture of the thin filament-Z-line junction: lessons from nebulette and nebulin homologies.Journal of muscle research and cell motility · 2000Article
- Thin filament protein dynamics in fully differentiated adult cardiac myocytes: toward a model of sarcomere maintenance.The Journal of cell biology · 1999Article
- Filament lengths in frog semitendinosus and tibialis anterior muscle fibres.Journal of muscle research and cell motility · 1993Article
- Expression and organization of muscle specific proteins during the early developmental stages of the rabbit heart.Anatomy and embryology · 1992Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Tropomyosin localization in striated muscle was studied by means of immunoelectron microscopy. Polyclonal and monoclonal antibodies to tropomyosin were allowed to diffuse into mechanically skinned single fibres dissected from frog semitendinosus muscle. Antibodies produced transverse I-band stripes with the expected periodicity of 38 nm. However, some differences were revealed among the various antibodies. While polyclonal antibodies generally showed 23 stripes, monoclonal antibodies showed an extra 24th stripe immediately adjacent to the Z-line, implying some structural/functional uniqueness of this terminal tropomyosin. Furthermore, the stripes did not always lie parallel to the Z-line. When the Z-line was straight or slightly skewed, the stripes generally were parallel to it. However, when Z-line skew was more severe, the stripes remained perpendicular to the fibre axis, indifferent to the Z-line skew. This may implay that the coupling of tropomyosin to the thin filament is not tight. Finally, the monoclonal antibodies themselves exerted an anomalous effect on the Z-line, apparently extracting or shifting some of its mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.