Evidence map›Paper›PMID 22661641›Full record

ReviewBiological research for nursing2013

Epigenetic regulation and measurement of epigenetic changes.

Kimberly E Stephens, Christine A Miaskowski, Jon D Levine, Clive R Pullinger, Bradley E Aouizerat

Abstract readReview
In one paragraph

Review in Biological research for nursing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Role of Hydrogen Sulfide (HInternational journal of molecular sciences · 2023
    Pooled it
  2. Review
  3. Epidrugs in cancer: mechanisms, applications, and future direction.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Interrogating the regulatory epigenome of cellular senescence.Cellular and molecular life sciences : CMLS · 2025
    Review
  8. Article
  9. DNA Satellites Impact Begomovirus Diseases in a Virus-Specific Manner.International journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Physiological and Epigenetic Reaction of Barley (International journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kimberly E Stephens1Department of Physiological Nursing, University of California, San Francisco, CA, USA.
Christine A Miaskowski
Jon D Levine
Clive R Pullinger
Bradley E Aouizerat

Funding

NURSING RESEARCH TRAINING IN SYMPTOM MANAGEMENTT32NR007088 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, KATHRYN · 1996 to 2015
$7.5M
Multidisciplinary Clinical Research Careers Program(RMI)K12RR023262 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HULLEY, STEPHEN B. · 2005 to 2006
$2.8M
NCRR NIH HHS K12 RR023262NCRR NIH HHS K12RR023262NINR NIH HHS T32 NR007088NINR NIH HHS T32 NR07088
6 · The paper itself

Abstract

Epigenetic mechanisms provide an adaptive layer of control in the regulation of gene expression that enables an organism to adjust to a changing environment. Epigenetic regulation increases the functional complexity of deoxyribonucleic acid (DNA) by altering chromatin structure, nuclear organization, and transcript stability. These changes may additively or synergistically influence gene expression and result in long-term molecular and functional consequences independent of the DNA sequence that may ultimately define an individual's phenotype. This article (1) describes histone modification, DNA methylation, and expression of small noncoding RNA species; (2) reviews the most common methods used to measure these epigenetic changes; and (3) presents factors that need to be considered when choosing a specific tissue to evaluate for epigenetic changes.

Indexed as

ChromatinDNA MethylationEpigenesis, GeneticHistonesHumansPhenotypeRNA, Small UntranslatedChromatinHistonesRNA, Small UntranslatedDNA methylationepigeneticshistone modificationsmall untranslated RNA

Identifiers

PMID22661641
PMCPMC5839622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.