Interleukin-18: the master regulator driving destructive and remodeling processes in the lungs of patients with chronic obstructive pulmonary disease?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets.Respiratory research · 2022
   Article
2. Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts.Respirology (Carlton, Vic.) · 2022
   Article
3. Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression.American journal of physiology. Lung cellular and molecular physiology · 2021
   Article
4. N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN-Computational and mathematical methods in medicine · 2021
   Article
5. IL-18 and related function proteins associated with tuberculosis severity and screening for active TB among patients with non-mycobacterial community-acquired pneumonia (CAP).Saudi journal of biological sciences · 2020
   Article
6. A comprehensive pathway map of IL-18-mediated signalling.Journal of cell communication and signaling · 2020
   Article
7. Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases.Cytokine & growth factor reviews · 2019
   Review
8. Emerging pharmaceutical therapies for COPD.International journal of chronic obstructive pulmonary disease · 2017
   Review
9. Cytokine inhibition in the treatment of COPD.International journal of chronic obstructive pulmonary disease · 2014
   Review
10. Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice.American journal of respiratory cell and molecular biology · 2013
    Article

Corrections and comments

• Comment on
  IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13.2012

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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