ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum load.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Diversity of cells and signals in the cardiovascular system.The Journal of physiology · 2023Article
- Cardiac Alternans: From Bedside to Bench and Back.Circulation research · 2023Review
- Activation of small conductance CaThe Journal of physiology · 2023Article
- The 'Reverse FDUF' Mechanism of Atrial Excitation-Contraction Coupling Sustains Calcium Alternans-A Hypothesis.Biomolecules · 2022Article
- Mechanism of carvedilol induced action potential and calcium alternans.Channels (Austin, Tex.) · 2022Article
- Synchronization of spatially discordant voltage and calcium alternans in cardiac tissue.Physical review. E · 2022Article
- An ensemble of parameters from a robust Markov-based model reproduces L-type calcium currents from different human cardiac myocytes.PloS one · 2022Article
- Cardiac Alternans Occurs through the Synergy of Voltage- and Calcium-Dependent Mechanisms.Membranes · 2021Article
- Mitochondrial depolarization promotes calcium alternans: Mechanistic insights from a ventricular myocyte model.PLoS computational biology · 2021Article
- Heart failure-induced atrial remodelling promotes electrical and conduction alternans.PLoS computational biology · 2020Article
- Calcium Buffering in the Heart in Health and Disease.Circulation · 2019Review
- Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart.International journal of molecular sciences · 2019Review
- Stochastic coupled map model of subcellular calcium cycling in cardiac cells.Chaos (Woodbury, N.Y.) · 2019Article
- Action potential shortening rescues atrial calcium alternans.The Journal of physiology · 2019Article
- Transverse tubular network structures in the genesis of intracellular calcium alternans and triggered activity in cardiac cells.Journal of molecular and cellular cardiology · 2018Article
- Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity.Frontiers in physiology · 2018Review
- Membrane potential determines calcium alternans through modulation of SR CaJournal of molecular and cellular cardiology · 2017Article
- Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into CaClinical Medicine Insights. Cardiology · 2017Article
- Ca(2+)-activated chloride channel activity during Ca(2+) alternans in ventricular myocytes.Channels (Austin, Tex.) · 2016Article
- A unified theory of calcium alternans in ventricular myocytes.Scientific reports · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Intracellular calcium (Ca) alternans in cardiac myocytes have been shown in many experimental studies, and the mechanisms remain incompletely understood. We recently developed a "3R theory" that links Ca sparks to whole cell Ca alternans through three critical properties: randomness of Ca sparks; recruitment of a Ca spark by neighboring Ca sparks; and refractoriness of Ca release units. In this study, we used computer simulation of a physiologically detailed mathematical model of a ventricular myocyte couplon network to study how sarcoplasmic reticulum (SR) Ca load and other physiological parameters, such as ryanodine receptor sensitivity, SR uptake rate, Na-Ca exchange strength, and Ca buffer levels affect Ca alternans in the context of 3R theory. We developed a method to calculate the parameters used in the 3R theory (i.e., the primary spark rate and the recruitment rate) from the physiologically detailed Ca cycling model and paced the model periodically to elicit Ca alternans. We show that alternans only occurs for an intermediate range of the SR Ca load, and the underlying mechanism can be explained via its effects on the 3Rs. Furthermore, we show that altering the physiological parameters not only directly changes the 3Rs but also alters the SR Ca load, having an indirect effect on the 3Rs as well. Therefore, our present study links the SR Ca load and other physiological parameters to whole cell Ca alternans through the framework of the 3R theory, providing a general mechanistic understanding of Ca alternans in ventricular myocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.