ArticleInvestigative ophthalmology & visual science2012
Blood flow MRI of the human retina/choroid during rest and isometric exercise.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals.BMC ophthalmology · 2022Trial
- Adaptive scan intervals in ultrawide-field OCT angiography achieved by a bidirectional interleaved approach.Biomedical optics express · 2026Article
- Physical Activity and Macular Choroidal Circulation in Older Adults With Primary Open-Angle Glaucoma: A Swept-Source Optical Coherence Tomography Angiography Study.Translational vision science & technology · 2026Article
- Acute intraocular pressure responses changes during dynamic resistance training in primary open-angle glaucoma patients and age-matched controls.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Imaging the eye as a window to brain health: frontier approaches and future directions.Journal of neuroinflammation · 2024Review
- Effects of voluntary and forced physical exercise on the retinal health of aging Wistar rats.GeroScience · 2024Article
- The Effect of Diet and Lifestyle on the Course of Diabetic Retinopathy-A Review of the Literature.Nutrients · 2022Review
- Measurement of retina/choroid complex perfusion with magnetic resonance imaging in eyes with acute primary angle-closure.Arquivos brasileiros de oftalmologia · 2021Article
- Non-invasive Diagnosis and Prognosis Values of 3D Pseudocontinuous Arterial Spin Labeling and Optical Coherence Tomography Angiography in Proliferative Diabetic Retinopathy.Frontiers in medicine · 2021Article
- The Cardiovascular Stress Response as Early Life Marker of Cardiovascular Health: Applications in Population-Based Pediatric Studies-A Narrative Review.Pediatric cardiology · 2020Review
- Retinal Vascular Reactivity in Type 1 Diabetes Patients Without Retinopathy Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2020Article
- Voluntary running delays primary degeneration in rat retinas after partial optic nerve transection.Neural regeneration research · 2019Article
- A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography.Frontiers in neuroscience · 2019Article
- ASSESSMENT OF RETINAL BLOOD FLOW IN DIABETIC RETINOPATHY USING DOPPLER FOURIER-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.Retina (Philadelphia, Pa.) · 2017Article
- Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris.Biomedical optics express · 2016Article
- Label free measurement of retinal blood cell flux, velocity, hematocrit and capillary width in the living mouse eye.Biomedical optics express · 2016Article
- Clinical evaluation of ultra-high-field MRI for three-dimensional visualisation of tumour size in uveal melanoma patients, with direct relevance to treatment planning.Magma (New York, N.Y.) · 2016Article
- Application of Arterial Spin Labelling in the Assessment of Ocular Tissues.BioMed research international · 2016Review
- Measurement of retinal blood flow in normal Chinese-American subjects by Doppler Fourier-domain optical coherence tomography.Investigative ophthalmology & visual science · 2015Article
- Choroidal blood flow decreases with age: an MRI study.Current eye research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate blood flow (BF) in the human retina/choroid during rest and handgrip isometric exercise using magnetic resonance imaging (MRI).
methodsFour healthy volunteers (25-36 years old) in multiple sessions (1-3) on different days. MRI studies were performed on a 3-Tesla scanner using a custom-made surface coil (7×5cm in diameter) at the spatial resolution of 0.5×0.8×6.0 mm. BF was measured using the pseudo-continuous arterial-spin-labeling technique with background suppression and turbo-spin-echo acquisition. During MRI, subjects rested for 1 minute followed by 1 minute of handgrip, repeating three times, while maintaining stable eye fixation on a target with cued eye blinks at the end of each data acquisition (every 4.6 seconds).
resultsRobust BF of the unanesthetized human retina/choroid was detected. Basal BF in the posterior retina/choroid was 149±48 mL/100 mL/min with a mean heart rate of 60±5 beats per minute, mean arterial pressure of 78±5 mm Hg, ocular perfusion pressure of 67±4 mm Hg at rest (mean±SD, n=4 subjects). Handgrip significantly increased retina/choroid BF by 25%±7%, heart rate by 19%±8%, mean arterial pressure by 22%±5% (measured at the middle of the handgrip task), and ocular perfusion pressure by 25%±6% (averaged across the entire handgrip task) (P<0.01), but did not change intraocular pressure, arterial oxygen saturation, end-tidal CO2, and respiration rate (P>0.05).
conclusionsThis study demonstrates a novel MRI application to image quantitative BF of the human retina/choroid during rest and isometric exercise. Retina/choroid BF increases during brief handgrip exercise, paralleling increases in mean arterial pressure. Handgrip exercise changes ocular perfusion pressure free of potential drug side effect and can be done in the MRI scanner. MRI offers quantitative BF with large field of view without depth limitation, potentially providing insights into retinal pathophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.