ArticleGenetics2012
Dynamics of neutral and selected alleles when the offspring distribution is skewed.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Multiple merger coalescent inference of effective population size.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Reproductive variance can drive behavioral dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Efficient ancestry and mutation simulation with msprime 1.0.Genetics · 2022Article
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- Multiple Merger Genealogies in Outbreaks of Mycobacterium tuberculosis.Molecular biology and evolution · 2021Article
- How Much DoesGenetics · 2020Article
- Exploring the causes of small effective population sizes in cyst nematodes using artificial Globodera pallida populations.Proceedings. Biological sciences · 2019Article
- Article
- On selection in finite populations.Journal of mathematical biology · 2018Article
- Frequency-dependent selection in vaccine-associated pneumococcal population dynamics.Nature ecology & evolution · 2017Article
- On the stochastic evolution of finite populations.Journal of mathematical biology · 2017Article
- Dedicated population genomics for the silent world: the specific questions of marine population genetics.Current zoology · 2016Article
- Coalescent inferences in conservation genetics: should the exception become the rule?Biology letters · 2016Review
- Fate of a mutation in a fluctuating environment.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The equilibrium allele frequency distribution for a population with reproductive skew.Genetics · 2014Article
- Malaria life cycle intensifies both natural selection and random genetic drift.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Reference-free population genomics from next-generation transcriptome data and the vertebrate-invertebrate gap.PLoS genetics · 2013Article
- Molecular hyperdiversity and evolution in very large populations.Molecular ecology · 2013Article
- A high load of non-neutral amino-acid polymorphisms explains high protein diversity despite moderate effective population size in a marine bivalve with sweepstakes reproduction.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyze the dynamics of two alternative alleles in a simple model of a population that allows for large family sizes in the distribution of offspring number. This population model was first introduced by Eldon and Wakeley, who described the backward-time genealogical relationships among sampled individuals, assuming neutrality. We study the corresponding forward-time dynamics of allele frequencies, with or without selection. We derive a continuum approximation, analogous to Kimura's diffusion approximation, and we describe three distinct regimes of behavior that correspond to distinct regimes in the coalescent processes of Eldon and Wakeley. We demonstrate that the effect of selection is strongly amplified in the Eldon-Wakeley model, compared to the Wright-Fisher model with the same variance effective population size. Remarkably, an advantageous allele can even be guaranteed to fix in the Eldon-Wakeley model, despite the presence of genetic drift. We compute the selection coefficient required for such behavior in populations of Pacific oysters, based on estimates of their family sizes. Our analysis underscores that populations with the same effective population size may nevertheless experience radically different forms of genetic drift, depending on the reproductive mechanism, with significant consequences for the resulting allele dynamics.
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