ArticleGenes & development2012
Telomere end processing: unexpected complexity at the end game.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- A CRISPR/Cas9-induced blunt-end telomere system in S. pombe reveals RNase H2-dependent RNA primer removal at the terminal Okazaki fragment of lagging telomeres.Nucleic acids research · 2026Article
- Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues.Frontiers in aging · 2025Article
- Telomere maintenance in African trypanosomes.Frontiers in molecular biosciences · 2023Review
- Current understanding of genomic stability maintenancein pluripotent stem cells.Acta biochimica et biophysica Sinica · 2022Review
- Telomeres and Cancer.Life (Basel, Switzerland) · 2021Review
- TERRA Gene Expression in Gastric Cancer: Role of hTERT.Journal of gastrointestinal cancer · 2021Review
- Implications of telomeres and telomerase in endometrial pathology.Human reproduction update · 2017Review
- Genome instability of ageing stem cells--Induction and defence mechanisms.Ageing research reviews · 2015Review
- Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Aging cell · 2013Article
- Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer.Diagnostic pathology · 2013Article
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1 author.
Funding
Abstract
Most human cells lack telomerase, the enzyme that elongates telomeres. The resulting telomere erosion eventually limits cell proliferation and tissue renewal, thereby impacting age-dependent pathologies. In this issue of Genes & Development, a technical tour-de-force by Chow and colleagues (pp. 1167-1178) reveals a highly choreographed sequence of events that processes newly replicated chromosome ends into mature telomeres. This sheds new light on an underappreciated contribution to telomere dynamics that may be as important as telomerase in dictating the correlation between life span and telomere length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.