ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2012
miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Revisiting the role of MicroRNAs in the pathogenesis of idiopathic pulmonary fibrosis.Frontiers in cell and developmental biology · 2024Review
- The emerging role of epigenetic regulation in the progression of silicosis.Clinical epigenetics · 2022Review
- Article
- Caveolin-1 as a pathophysiological factor and target in psoriasis.NPJ aging and mechanisms of disease · 2019Review
- The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis.Scientific reports · 2017Article
- MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics.Acta pharmaceutica Sinica. B · 2016Review
- Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Decreased expression of microRNA-29 family in leiomyoma contributes to increased major fibrillar collagen production.Fertility and sterility · 2016Article
- miR-31 is distinctively overexpressed in primary male extramammary Paget's disease.Oncotarget · 2016Article
- miR-1343 attenuates pathways of fibrosis by targeting the TGF-β receptors.The Biochemical journal · 2016Article
- Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis.Stem cells international · 2016Review
- Interaction of long noncoding RNAs and microRNAs in the pathogenesis of idiopathic pulmonary fibrosis.Physiological genomics · 2015Article
- The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis.Scientific reports · 2015Article
- Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- A microrna screen to identify regulators of peritoneal fibrosis in a rat model of peritoneal dialysis.BMC nephrology · 2015Article
- Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition.Archives of biochemistry and biophysics · 2015Article
- The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion.Molecular oncology · 2013Article
- Epigenetics in immune-mediated pulmonary diseases.Clinical reviews in allergy & immunology · 2013Review
- MicroRNA let-7c regulates macrophage polarization.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
- Retraction · 2013-02-01Duplication of/in Image · Objections by Author(s) ·
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant expression of miRNAs is closely associated with initiation and progression of pathological processes, including diabetes, cancer, and cardiovascular disease. However, the role of miRNAs in lung fibrosis is not well characterized. We sought to determine the role of miR-31 in regulating the fibrogenic, contractile, and migratory activities of lung fibroblasts and modulating of pulmonary fibrosis in vivo. In vivo lung fibrosis models and ex vivo cell culture systems were employed. Real-time PCR and Western blot analysis were used to determine gene expression levels. miR-31 mimics or inhibitors were transfected into pulmonary fibroblasts. Fibrogenic, contractile, and migratory activities of lung fibroblasts were determined. We found that miR-31 expression is reduced in the lungs of mice with experimental pulmonary fibrosis and in IPF fibroblasts. miR-31 inhibits the profibrotic activity of TGF-β1 in normal lung fibroblasts and diminishes the fibrogenic, contractile, and migratory activities of IPF fibroblasts. In these experiments, miR-31 was shown to directly target integrin α(5) and RhoA, two proteins that have been shown to regulate activation of fibroblasts. We found that levels of integrin α(5) and RhoA are up-regulated in fibrotic mouse lungs. Knockdown of integrin α(5) and RhoA attenuated fibrogenic, contractile, and migratory activities of IPF fibroblasts, in a manner similar to that observed with miR-31. We also found that introduction of miR-31 ameliorated experimental lung fibrosis in mice. Our data suggest that miR-31 is an important regulator of the pathological activities of lung fibroblasts and may be a potential target in the development of novel therapies to treat pathological fibrotic disorders, including pulmonary fibrosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.