ArticleAntonie van Leeuwenhoek2012
Staphylococcus haemolyticus strains target mitochondria and induce caspase-dependent apoptosis of macrophages.
Article in Antonie van Leeuwenhoek, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Staphylococcal mastitis in dairy cows.Frontiers in veterinary science · 2024Review
- Clinical Infections, Antibiotic Resistance, and Pathogenesis ofMicroorganisms · 2022Review
- Pathogenesis ofVirulence · 2020Article
- Multifactorial mechanisms of the pathogenesis of methicillin-resistant Staphylococcus hominis isolated from bloodstream infections.Antonie van Leeuwenhoek · 2018Article
- Diversity of staphylococcal cassette chromosome mec elements in nosocomial multiresistant Staphylococcus haemolyticus isolates.Journal of applied genetics · 2016Article
- In Vitro Activity of Rifampicin Combined with Daptomycin or Tigecycline on Staphylococcus haemolyticus Biofilms.Current microbiology · 2015Article
- Can apoptosis and necrosis coexist in ejaculated human spermatozoa during in vitro semen bacterial infection?Journal of assisted reproduction and genetics · 2015Article
- Virulence and the presence of aminoglycoside resistance genes of Staphylococcus haemolyticus strains isolated from clinical specimens.Antonie van Leeuwenhoek · 2015Article
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Authors and funding
3 authors.
Funding
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Abstract
The aim of this study was to investigate the interaction of Staphylococcus haemolyticus strains with a macrophage cell line. Infection with the strains resulted in macrophage injury. All strains exhibited cytotoxic effects towards J774 cells. Moreover, the bacteria triggered apoptosis of the cells. The lowest apoptotic index did not exceed 21 %, whereas the highest reached 70 % at 24 h and 85 % at 48 h after infection. Incubation with the bacteria caused loss of mitochondrial membrane potential (ΔΨm) in macrophages. The pro-apoptotic activity of the strains was blocked by a pan-caspase inhibitor z-VAD-fmk, indicating the involvement of caspases in the bacteria-mediated cell death. We observed that the induction of macrophage apoptosis could constitute an important mechanism of pathogenesis by which S. haemolyticus strains evade host immune defences and cause disease.
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