Evidence map›Paper›PMID 22660936›Full record

ReviewPediatric nephrology (Berlin, Germany)2013

MicroRNAs in renal development.

Jacqueline Ho, Jordan A Kreidberg

Open access · greenAbstract readReview
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Non-Coding RNAs in Hereditary Kidney Disorders.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2016
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. MicroRNAs in Diabetic Kidney Disease.International journal of endocrinology · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jacqueline HoDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. jacqueline.ho2@chp.edu
Jordan A Kreidberg
Children's Hospital · TNUniversity of Pittsburgh · US

Funding

BMP and FGF Signaling in kidney progenitor cellsR01DK087794 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KREIDBERG, JORDAN A · 2010 to 2013
$1.5M
Misregulation of receptor tyrosine kinase signaling in PKDR01DK091295 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KREIDBERG, JORDAN A · 2011 to 2014
$1.4M
MicroRNAs in Kidney Progenitor Cells.R00DK087922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2012 to 2014
$722k
MicroRNAs in kidney progenitor cells.K99DK087922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2010 to 2011
$216k
NIDDK NIH HHS 1K99DK087922NIDDK NIH HHS K99 DK087922NIDDK NIH HHS R00 DK087922NIDDK NIH HHS R01 DK087794NIDDK NIH HHS R01DK087794NIDDK NIH HHS R01 DK091295NIDDK NIH HHS R01DK091295
6 · The paper itself

Abstract

The discovery of microRNAs (miRNAs) as novel regulators of gene expression has led to a marked change in how gene regulation is viewed, with important implications for development and disease. MiRNAs are endogenous, small, noncoding RNAs that largely repress their target mRNAs post-transcriptionally. The regulation of gene expression by miRNAs represents an evolutionarily conserved mechanism that is broadly applicable to most biological processes. Recent studies have begun to define the role of miRNAs in different cell lineages during kidney development, and to implicate specific miRNAs in developmental and pathophysiological processes in the kidney. This review will focus on novel insights into the role(s) of miRNAs in kidney development, and discuss the implications for pediatric renal disease.

Indexed as

Gene Expression RegulationHumansKidneyKidney DiseasesMicroRNAsMicroRNAs

Identifiers

PMID22660936
PMCPMC3720129
OpenAlexW2053950405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.