ArticleProceedings of the National Academy of Sciences of the United States of America2012
Biomimetic emulsions reveal the effect of mechanical forces on cell-cell adhesion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 87 citations in OpenAlex.
- Effect of adhesive properties of buffy coat on the quality of blood components produced with Top & Top and Top & Bottom bags.Blood transfusion = Trasfusione del sangue · 2015Trial
- Adhesion differentials control the rheology of biomimetic emulsions.Biophysical journal · 2026Article
- Design and optimization of in situ self-functionalizing stress sensors.The European physical journal. E, Soft matter · 2026Article
- Biomechanics-Driven 3D Architecture Inference from Histology Using CellSqueeze3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Observation of Brownian elastohydrodynamic forces acting on confined soft colloids.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mannose Ligands for Mannose Receptor Targeting.International journal of molecular sciences · 2024Review
- Push-pull mechanics of E-cadherin ectodomains in biomimetic adhesions.Biophysical journal · 2023Article
- A coarse-grained simulation model for colloidal self-assemblySoft matter · 2023Article
- Article
- Enhancing membrane-based soft materials with magnetic reconfiguration events.Scientific reports · 2022Article
- DNA self-organization controls valence in programmable colloid design.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue.Regenerative therapy · 2020Review
- Photo-printing of faceted DNA patchy particles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Design and Application of Stimulus-Responsive Droplets and Bubbles Stabilized by Phospholipid Monolayers.Current opinion in colloid & interface science · 2019Article
- Multivalent, multiflavored droplets by design.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Biological tissue-inspired tunable photonic fluid.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly.ACS central science · 2018Article
- Sequential self-assembly of DNA functionalized droplets.Nature communications · 2017Article
- Cis and Trans Cooperativity of E-Cadherin Mediates Adhesion in Biomimetic Lipid Droplets.Biophysical journal · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-cell contacts in tissues are continuously subject to mechanical forces due to homeostatic pressure and active cytoskeleton dynamics. In the process of cellular adhesion, the molecular pathways are well characterized but the role of mechanics is less well understood. To isolate the role of pressure we present a dense packing of functionalized emulsion droplets in which surface interactions are tuned to mimic those of real cells. By visualizing the microstructure in 3D we find that a threshold compression force is necessary to overcome electrostatic repulsion and surface elasticity and establish protein-mediated adhesion. Varying the droplet interaction potential maps out a phase diagram for adhesion as a function of force and salt concentration. Remarkably, fitting the data with our theoretical model predicts binder concentrations in the adhesion areas that are similar to those found in real cells. Moreover, we quantify the dependence of the area of adhesion on the applied force and thus reveal adhesion strengthening with increasing external pressure even in the absence of active cellular processes. This biomimetic approach reveals a physical origin of pressure-sensitive adhesion and its strength across cell-cell junctions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.