ArticlePediatric nephrology (Berlin, Germany)2012
Oxidative stress in hypertensive children before and after 1 year of antihypertensive therapy.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Cardiovascular Assessments in Children and Adolescents With Hypertension.Reviews in cardiovascular medicine · 2025Review
- Oxidative Stress and Endothelial Dysfunction: The Pathogenesis of Pediatric Hypertension.International journal of molecular sciences · 2025Review
- Oxidative stress and pediatric diabetic cardiovascular complications: emerging research and clinical applications.American journal of physiology. Heart and circulatory physiology · 2025Review
- Childhood Cardiovascular Health, Obesity, and Some Related Disorders: Insights into Chronic Inflammation and Oxidative Stress.International journal of molecular sciences · 2024Review
- Pathophysiology of primary hypertension in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2024Review
- Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Racial differences of early vascular aging in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2021Review
- Obesity, metabolic syndrome, and primary hypertension.Pediatric nephrology (Berlin, Germany) · 2021Article
- The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors.Antioxidants (Basel, Switzerland) · 2021Review
- Asymmetric dimethylarginine is not a marker of arterial damage in children with glomerular kidney diseases.Central-European journal of immunology · 2019Article
- Why should we screen for arterial hypertension in children and adolescents?Pediatric nephrology (Berlin, Germany) · 2018Review
- Primary hypertension is a disease of premature vascular aging associated with neuro-immuno-metabolic abnormalities.Pediatric nephrology (Berlin, Germany) · 2016Review
- The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study.Age (Dordrecht, Netherlands) · 2016Article
- Associations of the eNOS G894T gene polymorphism with target organ damage in children with newly diagnosed primary hypertension.Pediatric nephrology (Berlin, Germany) · 2015Article
- Metabolic syndrome in children with chronic kidney disease and after renal transplantation.Pediatric nephrology (Berlin, Germany) · 2014Review
- Primary hypertension in children and adolescents is an immuno-metabolic disease with hemodynamic consequences.Current hypertension reports · 2013Review
- Asymmetric and symmetric dimethylarginine in adolescents with hyperuricemia.Disease markers · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relation between primary hypertension (PH), target organ damage (TOD) and oxidative stress (SOX) is not known.
methodsWe assessed SOX in 86 children with PH before and after 12 months of standard non-pharmacological and pharmacological therapy based on renin-angiotensin system blockade.
resultsPatients with left ventricular hypertrophy (LVH) and with carotid intima-media thickness (cIMT) >2SDS had higher thiobarbituric acid reactive substances (TBARS) concentrations in comparison to patients without LVH or with normal cIMT. Patients with metabolic syndrome (MS) had lower activity of gluthatione peroxidase, higher asymmetric dimethyloarginine (ADMA) and oxidized LDL cholesterol (oxyLDL) in comparison to patients without MS. TBARS correlated with left ventricular concentric hypertrophy, cIMT, albuminuria and SBP/24 h. ADMA and oxyLDL correlated with CRP and TG/HDL ratio. After 1 year of antihypertensive treatment blood pressure, TOD and prevalence of MS decreased. TBARS decreased and glutathione concentrations increased. The decrease of TBARS concentration correlated with the decrease of body mass index (BMI). Decrease of oxyLDL and ADMA correlated with increased insulin sensitivity, however markers of SOX did not correlate with BP decrease.
conclusionSOX in children with PH correlates with TOD, metabolic abnormalities, changes in fat amount and improvement of insulin sensitivity, but not with BP decrease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.