ArticlePsychopharmacology2012
Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Independent association of tobacco use with opioid use disorder in patients of European ancestry with chronic non-cancer pain.Drug and alcohol dependence · 2020Trial
- Smokers with opioid use disorder may have worse drug use outcomes after varenicline than nicotine replacement.Journal of substance abuse treatment · 2019Trial
- The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction.Psychopharmacology · 2025Review
- Adolescent nicotine exposure affects later-life nicotine reward and withdrawal in mice.Pharmacology, biochemistry, and behavior · 2025Article
- Kappa-opioid receptor antagonism in the nucleus accumbens shell distinguishes escalated alcohol consumption and negative affective-like behavior from physiological withdrawal in alcohol-dependence.Pharmacology, biochemistry, and behavior · 2024Article
- Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes.International journal of molecular sciences · 2021Article
- Estradiol promotes and progesterone reduces anxiety-like behavior produced by nicotine withdrawal in female rats.Psychoneuroendocrinology · 2020Article
- Age and sex regulate kappa opioid receptor-mediated anxiety-like behavior in rats.Behavioural brain research · 2020Article
- Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.Neuropharmacology · 2019Article
- Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system.Alcohol (Fayetteville, N.Y.) · 2018Review
- Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis.Neuropharmacology · 2018Article
- A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Aqueous Extract of SemenEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Innovative approaches to support smoking cessation for individuals with mental illness and co-occurring substance use disorders.Expert review of respiratory medicine · 2017Review
- Tobacco use disorder and treatment: new challenges and opportunities.Dialogues in clinical neuroscience · 2017Review
- Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats.Neuropharmacology · 2017Article
- Endogenous opioid system: a promising target for future smoking cessation medications.Psychopharmacology · 2017Review
- Nicotine Increases Alcohol Intake in Adolescent Male Rats.Frontiers in behavioral neuroscience · 2017Article
- Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice.Neuropharmacology · 2015Article
- New mechanisms and perspectives in nicotine withdrawal.Neuropharmacology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleMechanisms that mediate age differences during nicotine withdrawal are unclear.
objectiveThis study compared kappa-opioid receptor (KOR) activation in naïve and nicotine-treated adolescent and adult rats using behavioral and neurochemical approaches to study withdrawal.
methodsThe behavioral models used to assess withdrawal included conditioned place and elevated plus maze procedures. Deficits in dopamine transmission in the nucleus accumbens (NAcc) were examined using microdialysis procedures. Lastly, the effects of KOR stimulation and blockade on physical signs produced upon removal of nicotine were examined in adults.
resultsNicotine-treated adults displayed a robust aversion to an environment paired with a KOR agonist versus naïve adults. Neither of the adolescent groups displayed a place aversion. KOR activation produced an increase in anxiety-like behavior that was highest in nicotine-treated adults versus all other groups. KOR activation produced a decrease in NAcc dopamine that was largest in nicotine-treated adults versus all other groups. Lastly, KOR activation facilitated physical signs of withdrawal upon removal of nicotine and KOR blockade reduced this effect.
conclusionChronic nicotine enhanced the affective, anxiogenic, and neurochemical effects produced by KOR activation in adult rats. Our data suggest that chronic nicotine elicits an increase in KOR function, and this may contribute to nicotine withdrawal since KOR activation facilitated and KOR blockade prevented withdrawal signs upon removal of nicotine. Given that chronic nicotine facilitated the neurochemical effects of KOR agonists in adults but not in adolescents, it is suggested that KOR regulation of mesolimbic dopamine may contribute to age differences in nicotine withdrawal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.