ArticleOsteoarthritis and cartilage2012
Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters.
Article in Osteoarthritis and cartilage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The Effect of Physical, Biochemical, and Electrical Culture Conditions on Articular Chondrocytes Used for Cartilage Tissue Engineering: A Narrative Review.International journal of molecular sciences · 2026Review
- Characterisation of Cartilage Damage via Fusing Mid-Infrared, Near-Infrared, and Raman Spectroscopic Data.Journal of personalized medicine · 2023Article
- Spatial correlation of native and engineered cartilage components at micron resolution.Annals of the New York Academy of Sciences · 2019Article
- Composition, structure and tensile biomechanical properties of equine articular cartilage during growth and maturation.Scientific reports · 2018Article
- Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties.The Analyst · 2017Article
- Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging.Faraday discussions · 2016Article
- Nondestructive Assessment of Engineered Cartilage Composition by Near Infrared Spectroscopy.Annals of biomedical engineering · 2016Article
- Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy.Cartilage · 2015Article
- FTIR-I compositional mapping of the cartilage-to-bone interface as a function of tissue region and age.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues.PloS one · 2013Article
- Infrared fiber optic probe evaluation of degenerative cartilage correlates to histological grading.The American journal of sports medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate whether Fourier transform infrared imaging spectroscopy (FT-IRIS), a modality based on molecular vibrations, is a viable alternative to histology and immunohistochemistry (IHC) for assessment of tissue quality and patient clinical outcome.
methodsOsteochondral biopsies were obtained from patients (9-65 months post-surgery) who underwent an autologous chondrocyte implantation (ACI) procedure to repair a cartilage defect (N = 14). The repair tissue was evaluated histologically by OsScore grading, for the presence of types I and II collagen by IHC, and for proteoglycan (PG) distribution and collagen quality parameters by FT-IRIS. Patient clinical outcome was assessed by the Lysholm score.
resultsImprovement in Lysholm score occurred in 79% of patients. IHC staining showed the presence of types I and II collagen in all samples, with a greater amount of collagen type II in the deep zone. The amount and location of immunostaining for type II collagen correlated to the FT-IRIS-derived parameters of relative PG content and collagen helical integrity. In addition, the improvement in Lysholm score post-ACI correlated positively with the OsScore, type II collagen (IHC score) and FT-IRIS-determined parameters. Regression models for the relation between improvement in Lysholm score and either OsScore, IHC area score or the FT-IRIS parameters all reached significance (p < 0.01). However, the FT-IRIS model was not significantly improved with inclusion of the OsScore and IHC score parameters.
conclusionDemonstration of the correlation between FT-IRIS-derived molecular parameters of cartilage repair tissue and patient clinical outcome lays the groundwork for translation of this methodology to the clinical environment to aid in the management of cartilage disorders and their treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.