ArticleJournal of proteomics2012
Neuronal porosome proteome: Molecular dynamics and architecture.
Article in Journal of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CK19 stabilizes CFTR at the cell surface by limiting its endocytic pathway degradation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients.Journal of proteomics · 2018Article
- Neuronal Porosome Complex: Secretory Machinery at the Nerve Terminal.Discoveries (Craiova, Romania) · 2017Review
- Fusion Pore: A Curious Case of Rediscovering Science.Discoveries (Craiova, Romania) · 2017Article
- Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells.Endocrinology · 2016Article
- The neuronal porosome complex in health and disease.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- 'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion.Journal of cellular and molecular medicine · 2015Review
- Article
- Neuronal porosome lipidome.Journal of cellular and molecular medicine · 2014Article
- Porosome: a membrane microdomain acting as the universal secretory portal in exocytosis.Discoveries (Craiova, Romania) · 2014Review
- Discoveries Interview: Professor Bhanu P. Jena on the discovery of the porosome, the universal machinery for cellular secretion.Discoveries (Craiova, Romania) · 2014Article
- NeuronalJournal of molecular structure · 2014Article
- Porosome in the Exocrine Pancreas: A Detailed EM Study suppressor.Discoveries (Craiova, Romania) · 2014Article
- Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR).Journal of proteomics · 2014Article
- What are lipoproteins doing in the brain?Trends in endocrinology and metabolism: TEM · 2014Article
- Function suggests nano-structure: towards a unified theory for secretion rate, a statistical mechanics approach.Journal of the Royal Society, Interface · 2013Article
- The protective effect of myo-inositol on hippocamal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus.Cellular and molecular neurobiology · 2013Article
- Discovery that cells have plasma membrane portals called porosomes that govern secretion.Discoveries (Craiova, Romania)Article
- Porosome in Cystic Fibrosis.Discoveries (Craiova, Romania)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Porosomes are the universal secretory portals at the cell plasma membrane, where membrane-bound secretory vesicles transiently dock and fuse to expel intravesicular contents to the outside during cell secretion. In the past decade, the neuronal porosome complex, a 10-15nm cup-shaped lipoprotein structure has been isolated, its partial composition and 3D contour map determined, and it has been functionally reconstituted into artificial lipid membrane. Here we further determine the composition of the neuronal porosome proteome using immunoisolation and gel filtration chromatography, followed by tandem mass spectrometry. Results from the study demonstrate nearly 40 proteins to constitute the neuronal porosome proteome. Furthermore, interaction of proteins within the porosome and their resulting arrangement is predicted. The association and dissociation of proteins at the porosome following stimulation of cell secretion demonstrate the dynamic nature of the organelle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.