ArticleActa biomaterialia2012
Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking.
Article in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Collagen-Based Microspheres for Biomedical Applications in Drug Delivery and Tissue Engineering.Biomimetics (Basel, Switzerland) · 2026Review
- Exploration of biomaterial-tissue integration in heterogeneous microporous annealed particle scaffolds in subcutaneous implants over 12 months.Acta biomaterialia · 2025Article
- Promoting Angiogenesis Using Immune Cells for Tissue-Engineered Vascular Grafts.Annals of biomedical engineering · 2023Review
- De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation.NPJ Regenerative medicine · 2023Article
- A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair.Frontiers in bioengineering and biotechnology · 2022Review
- Macrophage Polarization in Response to Biomaterials for Vascularization.Annals of biomedical engineering · 2021Review
- Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis.Advanced healthcare materials · 2019Review
- Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases.Stem cells international · 2019Review
- Injectable Supramolecular Hydrogel/Microgel Composites for Therapeutic Delivery.Macromolecular bioscience · 2019Article
- Differential degradation rate and underlying mechanism of a collagen/chitosan complex in subcutis, spinal cord and brain tissues of rat.Journal of materials science. Materials in medicine · 2018Article
- Biomimetic Approaches for Bone Tissue Engineering.Tissue engineering. Part B, Reviews · 2017Review
- Identification of different macrophage subpopulations with distinct activities in a mouse model of oxygen-induced retinopathy.International journal of molecular medicine · 2017Article
- Induced migration of endothelial cells into 3D scaffolds by chemoattractants secreted by pro-inflammatory macrophagesRegenerative biomaterials · 2017Article
- Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo.Annals of biomedical engineering · 2017Article
- Injectable Bioengineered Hydrogel Therapy in the Treatment of Ischemic Cardiomyopathy.Current treatment options in cardiovascular medicine · 2017Review
- How Biomaterials Can Influence Various Cell Types in the Repair and Regeneration of the Heart after Myocardial Infarction.Frontiers in bioengineering and biotechnology · 2016Review
- Macrophages modulate engineered human tissues for enhanced vascularization and healing.Annals of biomedical engineering · 2015Article
- Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.Biomaterials · 2015Article
- Targeted injection of a biocomposite material alters macrophage and fibroblast phenotype and function following myocardial infarction: relation to left ventricular remodeling.The Journal of pharmacology and experimental therapeutics · 2014Article
- The role of macrophage phenotype in vascularization of tissue engineering scaffolds.Biomaterials · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Injectable biomaterials alone may alter local tissue responses, including inflammatory cascades and matrix production (e.g. stimulatory dermal fillers are used as volumizing agents that induce collagen production). To expand upon the available material compositions and timing of presentation, a tunable hyaluronic acid (HA) and poly(lactide-co-glycolide) (PLGA) microsphere composite system was formulated and assessed in subcutaneous and cardiac tissues. HA functionalized with hydroxyethyl methacrylate (HeMA) was used as a precursor to injectable and degradable hydrogels that carry PLGA microspheres (~50 μm diameter) to tissues, where the HA hydrogel degradation (~20 or 70 days) and quantity of PLGA microspheres (0-300 mgml(-1)) are readily varied. When implanted subcutaneously, faster hydrogel degradation and more microspheres (e.g. 75 mgml(-1)) generally induced more rapid tissue and cellular interactions and a greater macrophage response. In cardiac applications, tissue bulking may be useful to alter stress profiles and to stabilize the tissue after infarction, limiting left ventricular (LV) remodeling. When fast degrading HeMA-HA hydrogels containing 75 mgml(-1) microspheres were injected into infarcted tissue in sheep, LV dilation was limited and the thickness of the myocardial wall and the presence of vessels in the apical infarct region were increased ~35 and ~60%, respectively, compared to empty hydrogels. Both groups decreased volume changes and infarct areas at 8 weeks, compared to untreated controls. This work illustrates the importance of material design in expanding the application of tissue bulking composites to a range of biomedical applications.
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Registered trials
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