Evidence map›Paper›PMID 22659063›Full record

ArticleMathematical biosciences2012

Concordant chemical reaction networks.

Guy Shinar, Martin Feinberg

Abstract read
In one paragraph

Article in Mathematical biosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Metrics for regulated biochemical pathway systems.Bioinformatics (Oxford, England) · 2019
    Article
  4. Article
  5. Article
  6. Article
  7. Dynamical properties of Discrete Reaction Networks.Journal of mathematical biology · 2014
    Article
  8. Translated chemical reaction networks.Bulletin of mathematical biology · 2014
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Guy ShinarDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel. shinarg@gmail.com
Martin Feinberg

Funding

Collaborative Research: Multistability in Biological NetworksR01GM086881 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI CRACIUN, GHEORGHE · 2008 to 2012
$1.5M
NIGMS NIH HHS R01 GM086881
6 · The paper itself

Abstract

We describe a large class of chemical reaction networks, those endowed with a subtle structural property called concordance. We show that the class of concordant networks coincides precisely with the class of networks which, when taken with any weakly monotonic kinetics, invariably give rise to kinetic systems that are injective - a quality that, among other things, precludes the possibility of switch-like transitions between distinct positive steady states. We also provide persistence characteristics of concordant networks, instability implications of discordance, and consequences of stronger variants of concordance. Some of our results are in the spirit of recent ones by Banaji and Craciun, but here we do not require that every species suffer a degradation reaction. This is especially important in studying biochemical networks, for which it is rare to have all species degrade.

Indexed as

Models, BiologicalModels, ChemicalKinetics

Identifiers

PMID22659063
PMCPMC4679294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.