ArticleJournal of molecular biology2012
Filaments from Ignicoccus hospitalis show diversity of packing in proteins containing N-terminal type IV pilin helices.
Article in Journal of molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- An archaellum filament composed of two alternating subunits.Nature communications · 2022Article
- Solubility and Aggregation of Selected Proteins Interpreted on the Basis of Hydrophobicity Distribution.International journal of molecular sciences · 2021Article
- An extensively glycosylated archaeal pilus survives extreme conditions.Nature microbiology · 2019Article
- Igni18, a novel metallo-hydrolase from the hyperthermophilic archaeon Ignicoccus hospitalis KIN4/I: cloning, expression, purification and X-ray analysis.Acta crystallographica. Section F, Structural biology communications · 2019Article
- Validation of a Hypothesis: Colonization of Black Smokers by Hyperthermophilic Microorganisms.Frontiers in microbiology · 2018Article
- Cryo-EM of bacterial pili and archaeal flagellar filaments.Current opinion in structural biology · 2017Review
- CryoEM structure of the Methanospirillum hungatei archaellum reveals structural features distinct from the bacterial flagellum and type IV pilus.Nature microbiology · 2016Article
- Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Motility and Ultrastructure ofFrontiers in microbiology · 2016Article
- Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives.FEMS microbiology reviews · 2015Review
- Life on the edge: functional genomic response of Ignicoccus hospitalis to the presence of Nanoarchaeum equitans.The ISME journal · 2015Article
- Editorial.FEMS microbiology reviews · 2015Article
- Ambiguities in helical reconstruction.eLife · 2014Article
- The Iho670 fibers of Ignicoccus hospitalis are anchored in the cell by a spherical structure located beneath the inner membrane.Journal of bacteriology · 2014Article
- Distinct docking and stabilization steps of the Pseudopilus conformational transition path suggest rotational assembly of type IV pilus-like fibers.Structure (London, England : 1993) · 2014Article
- Surface appendages of archaea: structure, function, genetics and assembly.Life (Basel, Switzerland) · 2013Review
- Identification of an additional minor pilin essential for piliation in the archaeon Methanococcus maripaludis.PloS one · 2013Article
- Structure and function of the adhesive type IV pilus of Sulfolobus acidocaldarius.Environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Bacterial motility is driven by the rotation of flagellar filaments that supercoil. The supercoiling involves the switching of coiled-coil protofilaments between two different states. In archaea, the flagellar filaments responsible for motility are formed by proteins with distinct homology in their N-terminal portion to bacterial Type IV pilins. The bacterial pilins have a single N-terminal hydrophobic α-helix, not the coiled coil found in flagellin. We have used electron cryo-microscopy to study the adhesion filaments from the archaeon Ignicoccus hospitalis. While I. hospitalis is non-motile, these filaments make transitions between rigid stretches and curved regions and appear morphologically similar to true archaeal flagellar filaments. A resolution of ~7.5Å allows us to unambiguously build a model for the packing of these N-terminal α-helices, and this packing is different from several bacterial Type IV pili whose structure has been analyzed by electron microscopy and modeling. Our results show that the mechanism responsible for the supercoiling of bacterial flagellar filaments cannot apply to archaeal filaments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.