Trial reportEpilepsy & behavior : E&B2012
The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory.
Trial report in Epilepsy & behavior : E&B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Severity of Topiramate-Related Working Memory Impairment Is Modulated by Plasma Concentration and Working Memory Capacity.Journal of clinical pharmacology · 2020Trial
- Brain's compensatory response to drug-induced cognitive impairment.Journal of clinical and experimental neuropsychology · 2018Trial
- Individual Differences in Working Memory Capacity Predict Topiramate-Related Cognitive Deficits.Journal of clinical psychopharmacology · 2018Trial
- Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers.Journal of clinical pharmacology · 2016Trial
- Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.British journal of clinical pharmacology · 2015Trial
- Drug-Induced Cognitive Impairment.Drug safety · 2025Review
- Preparation and evaluation of bilayer-core osmotic pump tablets contained topiramate.PloS one · 2022Article
- Working Memory Capacity Is Negatively Associated with Memory Load Modulation of Alpha Oscillations in Retention of Verbal Working Memory.Journal of cognitive neuroscience · 2019Article
- Review
- Effects of low-dose topiramate on language function in children with migraine.Korean journal of pediatrics · 2017Article
- Use of an automated mobile application to assess effects of nicotine withdrawal on verbal fluency: A pilot study.Experimental and clinical psychopharmacology · 2016Article
- Using Automatic Speech Recognition to Assess Spoken Responses to Cognitive Tests of Semantic Verbal Fluency.Speech communication · 2015Article
- Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Characterizing drug-induced stuttering in electronic health records.Journal of communication disordersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
This is the first study of the effect of topiramate on linguistic behavior and verbal recall using a computational linguistics system for automated language and speech analysis to detect and quantify drug-induced changes in speech recorded during discourse-level tasks. Healthy volunteers were administered a single, 100-mg oral dose of topiramate in two double-blind, randomized, placebo-controlled, crossover studies. Subjects' topiramate plasma levels ranged from 0.23 to 2.81 μg/mL. We found a significant association between topiramate levels and impairment on measures of verbal fluency elicited during a picture description task, correct number of words recalled on a paragraph recall test, and reaction time recorded during a working memory task. Using the tools of clinical pharmacology and computational linguistics, we elucidated the relationship between the determinants of a drug's disposition as reflected in plasma concentrations and their impact on cognitive functioning as reflected in spoken language discourse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.