ArticleThe Angle orthodontist2013
Mutagenicity and cytotoxicity in patients submitted to ionizing radiation.
Article in The Angle orthodontist, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Does cone-beam computed tomography examination increase the micronuclei frequency in the oral mucosa exfoliated cells? A systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Is micronucleus assay in oral exfoliated cells a suitable tool for biomonitoring children exposed to environmental pollutants? A systematic review.Environmental science and pollution research international · 2021Pooled it
- Risk Assessment of Genotoxicity and Cytotoxicity of Cone Beam Computed Tomography Exposure: A Systematic Review.Acta medica Philippina · 2026Article
- Genotoxic and cytotoxic effects of cone beam computed tomography on exfoliated epithelial cells in different age groups.BMC oral health · 2025Article
- Cone-beam computed tomography prescription by Brazilian orthodontists.Dental press journal of orthodontics · 2025Article
- Genotoxic and Cytotoxic Effects of Cone Beam Computed Tomography and Multidetector Computed Tomography on Exfoliated Buccal Epithelial Cells.Iranian journal of medical sciences · 2023Article
- Genotoxicity and cytotoxicity of cone beam computed tomography in children.BMC oral health · 2021Article
- Radiobiological risks following dentomaxillofacial imaging: should we be concerned?Dento maxillo facial radiology · 2021Review
- Value-addition of lateral cephalometric radiographs in orthodontic diagnosis and treatment planning.The Angle orthodontist · 2020Article
- Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers.The international journal of occupational and environmental medicine · 2020Article
- Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam computed tomography.Dento maxillo facial radiology · 2019Article
- Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam CT.Dento maxillo facial radiology · 2018Article
- Cytogenetic biomonitoring in individuals exposed to cone beam CT: comparison among exfoliated buccal mucosa cells, cells of tongue and epithelial gingival cells.Dento maxillo facial radiology · 2017Article
- Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes?Medicina oral, patologia oral y cirugia bucal · 2017Article
- The Genotoxic and Cytotoxic Effects of CT Scan on Buccal Epithelial Cells.Journal of cytologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate and compare mutagenicity (micronucleus) and cytotoxicity (karyorrhexis, pyknosis, and karyolysis) in exfoliated buccal mucosa cells of children following cone beam computed tomography (CBCT) or conventional radiograph exposure necessary for orthodontic planning. MATERIALS AND
methodsA total of 49 healthy children were submitted to CBCT or a conventional orthodontic radiographic protocol; they were divided into two groups based on exam: CBCT (n = 24) and Radiographic Set (n = 25) groups. The micronucleus test in the exfoliated buccal mucosa cells was applied.
resultsThere was not a statistically significant difference (P > .05) found between the number of micronucleated buccal mucosa cells (MNC) before and after exposure to radiation in either group, showing that neither group experienced a mutagenic effect. However, radiation did cause other nuclear alterations closely related to cytotoxicity, including karyorrhexis, pyknosis, and karyolysis, in both groups (P < .05). The CBCT group presented a greater increase in cell death than was noted in the Radiographic Set group (P < .044).
conclusionAccording to the micronucleus test, mutagenicity was not induced by the CBCT or the conventional radiographs, but cytotoxicity was verified after these exams, especially after CBCT. That might have happened once the CBCT group received a greater radiation dose than the Radiographic Set group as a result of the protocols used in orthodontic planning for this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.