ArticleUltrasonic imaging2012
Three-dimensional, extended field-of-view ultrasound method for estimating large strain mechanical properties of the cervix during pregnancy.
Article in Ultrasonic imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A finite element model of pregnancy derived from maternal sonography: effect of uterine and cervical structural properties on cervical mechanical loading.bioRxiv : the preprint server for biology · 2026Article
- Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth.Open journal of obstetrics and gynecology · 2024Article
- Pregnancy-induced remodeling of the murine reproductive tract: a longitudinal in vivo magnetic resonance imaging study.Scientific reports · 2024Article
- Roadmap on biomaterials for women's health.JPhys materials · 2023Article
- In vivo Raman spectroscopy monitors cervical change during labor.American journal of obstetrics and gynecology · 2022Article
- Cervical Augmentation with an Injectable Silk-Based Gel: Biocompatibility in a Rat Model of Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Computer modeling tools to understand the causes of preterm birth.Seminars in perinatology · 2017Review
- Prevention of preterm birth: Novel interventions for the cervix.Seminars in perinatology · 2017Review
- Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy.Journal of biomechanical engineering · 2017Article
- Function and failure of the fetal membrane: Modelling the mechanics of the chorion and amnion.PloS one · 2017Article
- Modeling the biomechanics of fetal movements.Biomechanics and modeling in mechanobiology · 2016Article
- Investigating the mechanical function of the cervix during pregnancy using finite element models derived from high-resolution 3D MRI.Computer methods in biomechanics and biomedical engineering · 2016Article
- Development of an ultrasonic method to detect cervical remodeling in vivo in full-term pregnant women.Ultrasound in medicine & biology · 2015Article
- The mechanical role of the cervix in pregnancy.Journal of biomechanics · 2015Review
- A continuous fiber distribution material model for human cervical tissue.Journal of biomechanics · 2015Article
- Effect of depth on shear-wave elastography estimated in the internal and external cervical os during pregnancy.Journal of perinatal medicine · 2014Article
- A simplified cervix model in response to induction balloon in pre-labour.Theoretical biology & medical modelling · 2013Article
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Authors and funding
6 authors.
Funding
Abstract
Cervical shortening and cervical insufficiency contribute to a significant number of preterm births. However, the deformation mechanisms that control how the cervix changes its shape from long and closed to short and dilated are not clear. Investigation of the biomechanical problem is limited by (1) lack of thorough characterization of the three-dimensional anatomical changes associated with cervical deformation and (2) difficulty measuring cervical tissue properties in vivo. The objective of the present study was to explore the feasibility of using three-dimensional ultrasound and fundal pressure to obtain anatomically-accurate numerical models of large-strain cervical deformation during pregnancy and enable noninvasive assessment of cervical-tissue compliance. Healthy subjects (n = 6) and one subject with acute cervical insufficiency in the midtrimester were studied. Extended field-of-view ultrasound images were obtained of the entire uterus and cervix. These images aided construction of anatomically accurate numerical models. Cervical loading was achieved with fundal pressure, which was quantified with a vaginal pressure catheter. In one subject, the anatomical response to fundal pressure was matched by a model-based simulation of the deformation response, thereby deriving the corresponding cervical mechanical properties and showing the feasibility of noninvasive assessment of compliance. The results of this pilot study demonstrate the feasibility of a biomechanical modeling framework for estimating cervical mechanical properties in vivo. An improved understanding of cervical biomechanical function will clarify the pathophysiology of cervical shortening.
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