ArticleJournal of nutrition and metabolism2012
Fetal programming of body composition, obesity, and metabolic function: the role of intrauterine stress and stress biology.
Article in Journal of nutrition and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Perceived stress and diet quality in women of reproductive age: a systematic review and meta-analysis.Nutrition journal · 2020Pooled it
- Maternal folate status and obesity/insulin resistance in the offspring: a systematic review.International journal of obesity (2005) · 2016Pooled it
- Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood.International journal of obesity (2005) · 2023Trial
- The Type of Dietary Fat in an Isocaloric Breakfast Meal Does Not Modify Postprandial Metabolism in Overweight/Obese Pregnant Women.Nutrients · 2019Trial
- Symptom burden in middle-aged women, the role of immigrant status.BMC public health · 2025Article
- Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.Psychoneuroendocrinology · 2025Article
- Maternal stress and fetoplacental cortisol regulation in small-for-gestational-age newborns.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh.Scientific reports · 2025Article
- Early Life Determinants of Overweight and Obesity in a Sample of Mexico City Preschoolers.Nutrients · 2025Article
- Prevalence and associated factors of psychological distress among caregivers of children with malnutrition: a cross‑sectional study.BMC public health · 2025Article
- New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility.Current obesity reports · 2025Review
- Perceived Stress During Late Pregnancy and Infant Body Composition at 1 Month.Journal of the Endocrine Society · 2025Article
- Prevalence and determinants of maternal psychological distress: A hospital- based cross-sectional study among pregnant women attending antenatal care in Dar-es-salaam, Tanzania.PLOS mental health · 2025Article
- MCM proteins are up-regulated in placentas of women with reduced insulin sensitivity.Bioscience reports · 2024Article
- Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy.International journal of obesity (2005) · 2023Article
- Maternal psychological distress and associated factors among pregnant women attending antenatal care at public hospitals, Ethiopia.PloS one · 2023Article
- Fetal programming of obesity and type 2 diabetes.World journal of diabetes · 2022Review
- Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines.Clinical epigenetics · 2022Article
- Mothers' Sexual Identity and Children's Health.Population research and policy review · 2022Article
- Relative Body Fat Distribution in Preadolescent Indian Children Exposed to a Natural Disaster during Early Development.International journal of environmental research and public health · 2022Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Epidemiological, clinical, physiological, cellular, and molecular evidence suggests that the origins of obesity and metabolic dysfunction can be traced back to intrauterine life and supports an important role for maternal nutrition prior to and during gestation in fetal programming. The elucidation of underlying mechanisms is an area of interest and intense investigation. In this perspectives paper we propose that in addition to maternal nutrition-related processes it may be important to concurrently consider the potential role of intrauterine stress and stress biology. We frame our arguments in the larger context of an evolutionary-developmental perspective that supports roles for both nutrition and stress as key environmental conditions driving natural selection and developmental plasticity. We suggest that intrauterine stress exposure may interact with the nutritional milieu, and that stress biology may represent an underlying mechanism mediating the effects of diverse intrauterine perturbations, including but not limited to maternal nutritional insults (undernutrition and overnutrition), on brain and peripheral targets of programming of body composition, energy balance homeostasis, and metabolic function. We discuss putative maternal-placental-fetal endocrine and immune/inflammatory candidate mechanisms that may underlie the long-term effects of intrauterine stress. We conclude with a commentary of the implications for future research and clinical practice.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.