ArticleFrontiers in plant science2012
Evolution and expression of tandem duplicated maize flavonol synthase genes.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 49 citations in OpenAlex.
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- Plant tolerance mechanisms to DNA-damaging UV stress.Journal of experimental botany · 2025Review
- Molecular mechanisms underlying gene regulatory variation of maize metabolic traits.The Plant cell · 2024Article
- Genome-Wide Association Study Reveals the Genetic Basis of Total Flavonoid Content in Brown Rice.Genes · 2023Article
- ThePlants (Basel, Switzerland) · 2023Article
- Maize Flavonoid Biosynthesis, Regulation, and Human Health Relevance: A Review.Molecules (Basel, Switzerland) · 2022Review
- The R2R3-MYB transcription factor MtMYB134 orchestrates flavonol biosynthesis in Medicago truncatula.Plant molecular biology · 2021Article
- Identification and functional characterization of a new flavonoid synthase gene MdFLS1 from apple.Planta · 2021Article
- Characterization of theFrontiers in plant science · 2021Article
- The Purple Leaf (Plants (Basel, Switzerland) · 2020Article
- Transgenic expression of flavanone 3-hydroxylase redirects flavonoid biosynthesis and alleviates anthracnose susceptibility in sorghum.Plant biotechnology journal · 2020Article
- Molecular cloning and expression characterization of flavonol synthase genes in peanut (Arachis hypogaea).Scientific reports · 2020Article
- Transcriptional differentiation of UV-B protectant genes in maize landraces spanning an elevational gradient in Chiapas, Mexico.Evolutionary applications · 2020Article
- Automatic Identification of Players in the Flavonoid Biosynthesis with Application on the Biomedicinal PlantPlants (Basel, Switzerland) · 2020Article
- Identification and evolutionary analysis of chalcone isomerase-fold proteins in ferns.Journal of experimental botany · 2020Article
- Insight into the evolution and functional characteristics of the pan-genome assembly from sesame landraces and modern cultivars.Plant biotechnology journal · 2019Article
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- Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis.BMC plant biology · 2017Article
- The Onion (Frontiers in plant science · 2016Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are specialized compounds widely distributed and with diverse functions throughout the plant kingdom and with several benefits for human health. In particular, flavonols, synthesized by flavonol synthase (FLS), protect plants against UV-B radiation and are essential for male fertility in maize and other plants. We have recently characterized a UV-B inducible ZmFLS1, corresponding to the first to be described in monocot plants. Interestingly, the new assembly of the B73 maize genome revealed the presence of a second putative FLS gene (ZmFLS2), with very high identity with ZmFLS1. ZmFLSs expression was analyzed in different maize tissues, and by combining electrophoretic mobility shift assays and transient expression experiments, we show that both genes are direct targets of anthocyanin (C1/PL1 + R/B) and 3-deoxy flavonoid (P1) transcriptional regulators. ZmFLS expression analyses show higher levels of both transcripts in high altitude landraces than inbred lines, and both genes are regulated by UV-B radiation in all lines analyzed. Moreover, the high sequence conservation of the ZmFLS promoters between maize lines suggests that the differences observed in ZmFLS expression are due to allelic variations in the transcription factors that regulate their activities. Finally, we generated pFLS1::FLS1-RFP transgenic plants and analyzed ZmFLS1 expression in different maize tissues; we found that this enzyme is localized in the ER and the perinuclear region.
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