ArticleFrontiers in plant science2012
Novel insights into regulation of asparagine synthetase in conifers.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Expansion and Nitrate-Responsive Expression of NRT3 Transport Regulators in Maritime Pine.Plants (Basel, Switzerland) · 2026Article
- The Multifaceted Functions of Plant Asparagine Synthetase: Regulatory Mechanisms and Functional Diversity in Growth and Defense.Plants (Basel, Switzerland) · 2026Review
- Article
- Under Stress: Searching for Genes Involved in the Response ofInternational journal of molecular sciences · 2024Article
- Coordinated regulation of the entry and exit steps of aromatic amino acid biosynthesis supports the dual lignin pathway in grasses.Nature communications · 2023Article
- Effect of Water Stress and Shading on Lime Yield and Quality.Plants (Basel, Switzerland) · 2023Article
- Transcriptome Analysis and Intraspecific Variation in Spanish Fir (International journal of molecular sciences · 2022Article
- A revised view on the evolution of glutamine synthetase isoenzymes in plants.The Plant journal : for cell and molecular biology · 2022Article
- Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat.Plants (Basel, Switzerland) · 2022Review
- Epitranscriptome changes triggered by ammonium nutrition regulate the proteome response of maritime pine roots.Frontiers in plant science · 2022Article
- Identification of Metabolic Pathways Differentially Regulated in Somatic and Zygotic Embryos of Maritime Pine.Frontiers in plant science · 2022Article
- Enzymes Involved in the Biosynthesis of Arginine from Ornithine in Maritime Pine (Plants (Basel, Switzerland) · 2020Article
- Inorganic Nitrogen Form Determines Nutrient Allocation and Metabolic Responses in Maritime Pine Seedlings.Plants (Basel, Switzerland) · 2020Article
- Association Mapping of Seed Quality Traits Under Varying Conditions of Nitrogen Application inFrontiers in genetics · 2020Article
- Resistance associated metabolite profiling of Aspergillus leaf spot in cotton through non-targeted metabolomics.PloS one · 2020Article
- Article
- Salt acclimation in sorghum plants by exogenous proline: physiological and biochemical changes and regulation of proline metabolism.Plant cell reports · 2019Article
- Cytokinin at the Crossroads of Abiotic Stress Signalling Pathways.International journal of molecular sciences · 2018Review
- PpNAC1, a main regulator of phenylalanine biosynthesis and utilization in maritime pine.Plant biotechnology journal · 2018Article
- Glutamate synthases from conifers: gene structure and phylogenetic studies.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asparagine, a key amino acid for nitrogen storage and transport in plants, is synthesized via the ATP-dependent reaction catalyzed by the enzyme asparagine synthetase (AS; EC 6.3.5.4). In this work, we present the molecular analysis of two full-length cDNAs that encode asparagine synthetase in maritime pine (Pinus pinaster Ait.), PpAS1, and PpAS2. Phylogenetic analyses of the deduced amino acid sequences revealed that both genes are class II AS, suggesting an ancient origin of these genes in plants. A comparative study of PpAS1 and PpAS2 gene expression profiles showed that PpAS1 gene is highly regulated by developmental and environmental factors, while PpAS2 is expressed constitutively. To determine the molecular mechanisms underpinning the differential expression of PpAS1, the promoter region of the gene was isolated and putative binding sites for MYB transcription factors were identified. Gel mobility shift assays showed that a MYB protein from Pinus taeda (PtMYB1) was able to interact with the promoter region of PpAS1. Furthermore, transient expression analyses in pine cells revealed a negative effect of PtMYB1 on PpAS1 expression. The potential role of MYB factors in the transcriptional regulation of PpAS1 in vascular cells is discussed.
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