ArticleFrontiers in immunology2012
Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model.
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 113 citations in OpenAlex.
- MALT1 alternative splicing-A molecular rheostat for balancing immune activation and homeostasis.Science advances · 2026Article
- Distribution modeling quantifies collective TScience advances · 2023Article
- Review
- May be adenosine an immuno-quorum-sensing signal?Purinergic signalling · 2022Article
- Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity.The Journal of experimental medicine · 2021Article
- Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses.Frontiers in immunology · 2021Review
- Modes of Communication between T Cells and Relevance for Immune Responses.International journal of molecular sciences · 2020Review
- Modeling cell-cell communication for immune systems across space and time.Current opinion in systems biology · 2019Review
- Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance.International immunology · 2019Article
- Cytokine-mediated communication: a quantitative appraisal of immune complexity.Nature reviews. Immunology · 2019Review
- Rethinking Communication in the Immune System: The Quorum Sensing Concept.Trends in immunology · 2019Review
- Quorum Sensing by Monocyte-Derived Populations.Frontiers in immunology · 2019Review
- The expanding role of systems immunology in decoding the T cell receptor repertoire.Current opinion in systems biology · 2018Article
- Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model.eLife · 2016Article
- Fluctuating fitness shapes the clone-size distribution of immune repertoires.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Defective quorum sensing of acute lymphoblastic leukemic cells: evidence of collective behavior of leukemic populations as semi-autonomous aberrant ecosystems.American journal of cancer research · 2016Article
- Article
- Role of quorum sensing in bacterial infections.World journal of clinical cases · 2015Review
- Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.Nature immunology · 2015Article
- Core principles of bacterial autoinducer systems.Microbiology and molecular biology reviews : MMBR · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Homeostasis of lymphocyte numbers is believed to be due to competition between cellular populations for a common niche of restricted size, defined by the combination of interactions and trophic factors required for cell survival. Here we propose a new mechanism: homeostasis of lymphocyte numbers could also be achieved by the ability of lymphocytes to perceive the density of their own populations. Such a mechanism would be reminiscent of the primordial quorum-sensing systems used by bacteria, in which some bacteria sense the accumulation of bacterial metabolites secreted by other elements of the population, allowing them to "count" the number of cells present and adapt their growth accordingly. We propose that homeostasis of CD4(+) T cell numbers may occur via a quorum-sensing-like mechanism, where IL-2 is produced by activated CD4(+) T cells and sensed by a population of CD4(+) Treg cells that expresses the high-affinity IL-2Rα-chain and can regulate the number of activated IL-2-producing CD4(+) T cells and the total CD4(+) T cell population. In other words, CD4(+) T cell populations can restrain their growth by monitoring the number of activated cells, thus preventing uncontrolled lymphocyte proliferation during immune responses. We hypothesize that malfunction of this quorum-sensing mechanism may lead to uncontrolled T cell activation and autoimmunity. Finally, we present a mathematical model that describes the key role of IL-2 and quorum-sensing mechanisms in CD4(+) T cell homeostasis during an immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.