ArticleFrontiers in endocrinology2012
Control and physiological determinants of sympathetically mediated brown adipose tissue thermogenesis.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Brown adipose tissue and tumor presence: a retrospective association analysis considering the role of body mass index.Lipids in health and disease · 2025Article
- Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases.International journal of molecular sciences · 2023Review
- Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy.Frontiers in endocrinology · 2022Review
- The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system.Cell and tissue research · 2021Review
- Lowering apolipoprotein CIII protects against high-fat diet-induced metabolic derangements.Science advances · 2021Article
- Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism.Redox biology · 2017Review
- The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses.Scientific reports · 2017Article
- Adipose tissue in control of metabolism.The Journal of endocrinology · 2016Review
- mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.Scientific reports · 2016Article
- A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk.Current hypertension reports · 2016Review
- Contributors to Metabolic Disease Risk Following Spinal Cord Injury.Current physical medicine and rehabilitation reports · 2016Article
- Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz.Biomedical physics & engineering express · 2016Article
- Hydrogel-Based Engineering of Beige Adipose Tissue.Journal of materials chemistry. B · 2015Article
- Cognitive and autonomic determinants of energy homeostasis in obesity.Nature reviews. Endocrinology · 2015Review
- Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes.International journal of obesity supplements · 2015Review
- Thermogenic potential and physiological relevance of human epicardial adipose tissue.International journal of obesity supplements · 2015Review
- Obesity-induced increases in sympathetic nerve activity: sex matters.Autonomic neuroscience : basic & clinical · 2015Article
- Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta.International journal of endocrinology · 2014Article
- The central administration of C75, a fatty acid synthase inhibitor, activates sympathetic outflow and thermogenesis in interscapular brown adipose tissue.Pflugers Archiv : European journal of physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown adipose tissue (BAT) represents a remarkable heat-producing tissue. The thermogenic potential of BAT is conferred by uncoupling protein 1, a protein found uniquely in brown adipocytes. BAT activity and capacity is controlled by the sympathetic nervous system (SNS), which densely innervates brown fat depots. SNS-mediated BAT thermogenesis is essentially governed by hypothalamic and brainstem neurons. BAT activity is also modulated by brain energy balance pathways including the very significant brain melanocortin system, suggesting a genuine involvement of SNS-mediated BAT thermogenesis in energy homeostasis. The use of positron emission tomography/computed tomography scanning has revealed the presence of well-defined BAT depots in the cervical, clavicular, and paraspinal areas in adult humans. The prevalence of these depots is higher in subjects exposed to low temperature and is also higher in women compared to men. Moreover, the prevalence of BAT decreases with age and body fat mass, suggesting that BAT could be involved in energy balance regulation and obesity in humans. This short review summarizes recent progress made in our understanding of the control of SNS-mediated BAT thermogenesis and of the determinants of BAT prevalence or detection in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.