ArticleFrontiers in endocrinology2012
Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Long-lasting redundantiScience · 2024Article
- Article
- Sexually dimorphic distribution of kiss1 and kiss2 in the brain of yellowtail clownfish, Amphiprion clarkii.Endocrine connections · 2022Article
- Identification of feline Kiss1 and distribution of immunoreactive kisspeptin in the hypothalamus of the domestic cat.The Journal of reproduction and development · 2019Article
- Characterization of kiss2 and kissr2 genes and the regulation of kisspeptin on the HPG axis in Cynoglossus semilaevis.Fish physiology and biochemistry · 2017Article
- Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System.Endocrinology and metabolism (Seoul, Korea) · 2016Review
- Sexual dimorphism in the hypophysiotropic tyrosine hydroxylase-positive neurons in the preoptic area of the teleost, Clarias batrachus.Biology of sex differences · 2015Article
- Looking for the bird Kiss: evolutionary scenario in sauropsids.BMC evolutionary biology · 2014Article
- RFamide Peptides in Early Vertebrate Development.Frontiers in endocrinology · 2014Review
- Neurobiological study of fish brains gives insights into the nature of gonadotropin-releasing hormone 1-3 neurons.Frontiers in endocrinology · 2013Review
- Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons.PloS one · 2013Article
- Increased expression of kisspeptin and GnRH forms in the brain of scombroid fish during final ovarian maturation and ovulation.Reproductive biology and endocrinology : RB&E · 2012Article
- Introduction to special topic-estrogenic control of hypothalamic GnRH neurons.Frontiers in endocrinology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kisspeptin was originally found as a peptide product of Kiss1 gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1, evolved in parallel during vertebrate lineage, and the kiss2 product also activates the GPR54 (kisspeptin receptor) signaling pathways. Therefore, it is now widely accepted that both kiss1 and kiss2 are the kisspeptin genes. Interestingly, either kiss1 or kiss2 or both have been lost during evolution in many vertebrate species, and the functional significance of kiss1 or kiss2 for the central regulation of reproduction is suggested to vary according to the species. Here, we argue that the steroid sensitivity of the kiss1 or kiss2 neurons has been well conserved during evolution among tetrapods and teleosts, and thus it may be the key to understanding the functional homologies of certain populations of kisspeptin (kiss1 or kiss2) neurons among different species of vertebrates. In the present review, we will first introduce recent advances in the study of steroid sensitive kiss1 and kiss2 systems in vertebrates and effects of peptide administrations in vivo. By comparing the similarities and differences between kiss1 and kiss2 of neuronal localization and sensitivity to gonadal steroids in various tetrapods and teleosts, we discuss the evolution of kisspeptin neuronal systems after gene duplication of ancestral kisspeptin genes to give rise to kiss1 and kiss2.
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