ArticleFrontiers in endocrinology2011
The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge.
Article in Frontiers in endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
- Sexual Dimorphism and Aging Effects on Pituitary Gonadotroph Structure and Secretion in Dromedary Camels: Immunohistochemical and Ultrastructural Insights.Veterinary sciences · 2026Article
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- Allopregnanolone: An overview on its synthesis and effects.Journal of neuroendocrinology · 2022Review
- Membrane estrogen signaling in female reproduction and motivation.Frontiers in endocrinology · 2022Review
- Neuroendocrine mechanisms underlying estrogen positive feedback and the LH surge.Frontiers in neuroscience · 2022Review
- Progesterone receptor-Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats.Journal of neuroendocrinology · 2022Article
- Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone.Frontiers in physiology · 2022Article
- Glial estradiol synthesis after brain injury.Current opinion in endocrine and metabolic research · 2021Article
- Progesterone Receptors in AVPV Kisspeptin Neurons Are Sufficient for Positive Feedback Induction of the LH Surge.Endocrinology · 2021Article
- HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status.GeroScience · 2021Article
- Hypothalamic Astrocyte Development and Physiology for Neuroprogesterone Induction of the Luteinizing Hormone Surge.Frontiers in endocrinology · 2020Review
- Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling.Journal of neuroendocrinology · 2018Review
- Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?Endocrine · 2018Review
- Neuroestradiol in regulation of GnRH release.Hormones and behavior · 2018Review
- Allopregnanolone alters follicular and luteal dynamics during the estrous cycle.Reproductive biology and endocrinology : RB&E · 2018Article
- Reduced Luteinizing Hormone Induction Following Estrogen and Progesterone Priming in Female-to-Male Transsexuals.Frontiers in endocrinology · 2018Article
- Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin Neurons.Neuroendocrinology · 2018Article
- On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Sex Differences in Steroid Receptor Coexpression and Circadian-Timed Activation of Kisspeptin and RFRP-3 Neurons May Contribute to the Sexually Dimorphic Basis of the LH Surge.Endocrinology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Our understanding the steroid regulation of neural function has rapidly evolved in the past decades. Not long ago the prevailing thoughts were that peripheral steroid hormones carried information to the brain which passively responded to these steroids. These steroid actions were slow, taking hours to days to be realized because they regulated gene expression. Over the past three decades, discoveries of new steroid receptors, rapid membrane-initiated signaling mechanisms, and de novo neurosteroidogenesis have shed new light on the complexity of steroids actions within the nervous system. Sexual differentiation of the brain during development occurs predominately through timed steroid-mediated expression of proteins and long term epigenetic modifications. In contrast across the estrous cycle, estradiol release from developing ovarian follicles initially increases slowly and then at proestrus increases rapidly. This pattern of estradiol release acts through both classical genomic mechanisms and rapid membrane-initiated signaling in the brain to coordinate reproductive behavior and physiology. This review focuses on recently discovered estrogen receptor-α membrane signaling mechanisms that estradiol utilizes during estrogen positive feedback to stimulate de novo progesterone synthesis within the hypothalamus to trigger the luteinizing hormone (LH) surge important for ovulation and estrous cyclicity. The activation of these signaling pathways appears to be coordinated by the rising and waning of estradiol throughout the estrous cycle and integral to the negative and positive feedback mechanisms of estradiol. This differential responsiveness is part of the timing mechanism triggering the LH surge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.