ArticleFrontiers in neurology2012
Cognitive dysfunction in multiple sclerosis.
Article in Frontiers in neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dementia in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Memantine for Multiple Sclerosis: A Systematic Review and Meta-Analysis of Randomized Trials.Frontiers in neurology · 2020Pooled it
- Motor, cognitive, and combined rehabilitation approaches on MS patients' cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Trial
- Motor reaction time and accuracy in patients with multiple sclerosis: effects of an active computerized training program.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Trial
- Variations in neuronal cytoskeletal integrity affect directed communication in distributed networks during inhibitory control.Communications biology · 2025Article
- Multiple sclerosis and the risk of dementia: a real-world, nationwide cohort study.Frontiers in neurology · 2025Article
- Therapeutic Options of Crystallin Mu and Protein Disulfide Isomerase A3 for Cuprizone-Induced Demyelination in Mouse Hippocampus.Neurochemical research · 2024Article
- Importance of Coping Strategies on Quality of Life in People with Multiple Sclerosis: A Systematic Review.Journal of clinical medicine · 2024Review
- Comparison between Motor Performance of People with Multiple Sclerosis during a Virtual Reality Task Practiced on Concrete and Abstract Devices: A Cross-Sectional Randomized Study.Brain sciences · 2024Article
- On the Move: Correlation of Impaired Mobility with Spatial Navigation Ability in Persons with Multiple Sclerosis.Brain sciences · 2024Article
- Understanding who benefits most from cognitive rehabilitation for multiple sclerosis: A secondary data analysis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Identification of cognitive load-dependent activation patterns using working memory task-based fMRI at various levels of difficulty.Scientific reports · 2023Article
- Cognitive impairment in multiple sclerosis: "classic" knowledge and recent acquisitions.Arquivos de neuro-psiquiatria · 2023Article
- Relationship of Motor Impairment with Cognitive and Emotional Alterations in Patients with Multiple Sclerosis.International journal of environmental research and public health · 2023Observational
- Comparison of the Effects of Cuprizone on Demyelination in the Corpus Callosum and Hippocampal Progenitors in Young Adult and Aged Mice.Neurochemical research · 2022Article
- Low-field magnetic stimulation improved cuprizone-induced depression-like symptoms and demyelination in female mice.Experimental and therapeutic medicine · 2022Article
- Information Processing Speed Assessed with Letter Digit Substitution Test in Croatian Sample of Multiple Sclerosis Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Real-time associations among MS symptoms and cognitive dysfunction using ecological momentary assessment.Frontiers in medicine · 2022Article
- The Wahls Behavior Change Model for Complex Chronic Diseases: A Clinician's Guide.Degenerative neurological and neuromuscular disease · 2022Article
- Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): discrete and regression-based norms for the Brazilian context.Arquivos de neuro-psiquiatria · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45-60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual-spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.