ReviewTheScientificWorldJournal2012
CD8+ T cells: GITR matters.
Review in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.BioMed research international · 2019Trial
- Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment.CPT: pharmacometrics & systems pharmacology · 2023Article
- Monocarboxylate transporter 1 deficiency impacts CD8iScience · 2022Article
- MMP2 and TLRs modulate immune responses in the tumor microenvironment.JCI insight · 2021Article
- Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation.Frontiers in immunology · 2021Review
- Human CD8BMC immunology · 2020Article
- Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression.Frontiers in immunology · 2018Article
- Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy.Journal for immunotherapy of cancer · 2017Article
- Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.PLoS pathogens · 2015Article
- Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.Journal of immunology research · 2015Review
- Expansion of regulatory GITR+CD25 low/-CD4+ T cells in systemic lupus erythematosus patients.Arthritis research & therapy · 2014Article
- Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.The Journal of experimental medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.