ArticleInternational journal of nanomedicine2012
Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial.Emerging microbes & infections · 2023Trial
- Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer.Cellular and molecular life sciences : CMLS · 2023Article
- In vitro evaluation of antiviral activity of Shouchella clausii probiotic strain and bacterial supernatant against herpes simplex virus type 1.Archives of microbiology · 2022Article
- Concentration optimization of combinatorial drugs using Markov chain-based models.BMC bioinformatics · 2021Article
- Comparative analysis of the tear protein profile in herpes simplex virus type 1 epithelial keratitis.BMC ophthalmology · 2020Article
- Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention.Advanced therapeutics · 2020Article
- Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation.Antiviral research · 2019Article
- COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining.BMC bioinformatics · 2019Article
- Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC-MS/MS method coupled with 96-well format plate.Journal of pharmaceutical and biomedical analysis · 2019Article
- Drug Combinations: Mathematical Modeling and Networking Methods.Pharmaceutics · 2019Review
- Feedback System Control Optimized Electrospinning for Fabrication of an Excellent Superhydrophobic Surface.Nanomaterials (Basel, Switzerland) · 2017Article
- Effective drug combination forScience advances · 2017Article
- Automatic optimization of drug cocktails on an integrated microfluidic system.Biomicrofluidics · 2017Article
- Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time.Nature communications · 2017Article
- Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Optimization of drug combinations using Feedback System Control.Nature protocols · 2016Article
- A streamlined search technology for identification of synergistic drug combinations.Scientific reports · 2015Article
- Nanodiamonds: The intersection of nanotechnology, drug development, and personalized medicine.Science advances · 2015Review
- Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer.Angiogenesis · 2015Article
- Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInfectious diseases cause many molecular assemblies and pathways within cellular signaling networks to function aberrantly. The most effective way to treat complex, diseased cellular networks is to apply multiple drugs that attack the problem from many fronts. However, determining the optimal combination of several drugs at specific dosages to reach an endpoint objective is a daunting task.
methodsIn this study, we applied an experimental feedback system control (FSC) method and rapidly identified optimal drug combinations that inhibit herpes simplex virus-1 infection, by only testing less than 0.1% of the total possible drug combinations.
resultsUsing antiviral efficacy as the criterion, FSC quickly identified a highly efficacious drug cocktail. This cocktail contained high dose ribavirin. Ribavirin, while being an effective antiviral drug, often induces toxic side effects that are not desirable in a therapeutic drug combination. To screen for less toxic drug combinations, we applied a second FSC search in cascade and used both high antiviral efficacy and low toxicity as criteria. Surprisingly, the new drug combination eliminated the need for ribavirin, but still blocked viral infection in nearly 100% of cases.
conclusionThis cascade search provides a versatile platform for rapid discovery of new drug combinations that satisfy multiple criteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.