ArticleGene regulation and systems biology2012
Quantification of Transcriptome Responses of the Rumen Epithelium to Butyrate Infusion using RNA-seq Technology.
Article in Gene regulation and systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 73 citations in OpenAlex.
- RNA-Seq Reveals Gastrointestinal Transcriptome Dynamics in Preweaning Yak Calves Fed Concentrate Supplements.Animals : an open access journal from MDPI · 2026Article
- High-protein feed elevates ruminal and plasma ammonia and is associated with altered open-field behavior in Suffolk sheep.Frontiers in veterinary science · 2026Article
- Identification of transcriptional regulators and signaling pathways mediating postnatal rumen growth and functional maturation in cattle.Journal of animal science · 2025Article
- Microbial inoculum effects on the rumen epithelial transcriptome and rumen epimural metatranscriptome in calves.Scientific reports · 2024Article
- Postnatal Growth and Development of the Rumen: Integrating Physiological and Molecular Insights.Biology · 2024Review
- The quality of Tibetan sheep meat from pastures was synergistically regulated by the rumen microbiota and related genes at different phenological stages.Frontiers in veterinary science · 2024Article
- Effect of a molasses-based liquid supplement on gastrointestinal tract barrier function, inflammation, and performance of newly received feedlot cattle before and after a transport stress.Journal of animal science · 2023Article
- Rumen Epithelial Development- and Metabolism-Related Genes Regulate Their Micromorphology and VFAs Mediating Plateau Adaptability at Different Ages in Tibetan Sheep.International journal of molecular sciences · 2022Article
- Impact of dietary supplementation of β-hydroxybutyric acid on performance, nutrient digestibility, organ development and serum stress indicators in early-weaned goat kids.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Microbiome network traits in the rumen predict average daily gain in beef cattle under different backgrounding systems.Animal microbiome · 2022Article
- Effects of Different Roughage Diets on Fattening Performance, Meat Quality, Fatty Acid Composition, and Rumen Microbe in Steers.Frontiers in nutrition · 2022Article
- Transcriptome Analysis of Bovine Rumen Tissue in Three Developmental Stages.Frontiers in genetics · 2022Article
- Butyrate Permeation across the Isolated Ovine Reticulum Epithelium.Animals : an open access journal from MDPI · 2020Article
- Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance.Journal of animal science and biotechnology · 2020Review
- Systematic identification of long intergenic non-coding RNAs expressed in bovine oocytes.Reproductive biology and endocrinology : RB&E · 2020Article
- Effect of Alfalfa Hay and Starter Feeding Intervention on Gastrointestinal Microbial Community, Growth and Immune Performance of Yak Calves.Frontiers in microbiology · 2020Article
- Deciphering the transcriptome of prepubertal buffalo mammary glands using RNA sequencing.Functional & integrative genomics · 2019Article
- Temporal dynamics in meta longitudinal RNA-Seq data.Scientific reports · 2019Article
- Propionate and butyrate induce gene expression of monocarboxylate transporter 4 and cluster of differentiation 147 in cultured rumen epithelial cells derived from preweaning dairy calves.Journal of animal science · 2018Article
- Comparative transcriptome analysis of rumen papillae in suckling and weaned Japanese Black calves using RNA sequencing.Journal of animal science · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Short-chain fatty acids (SCFAs), such as butyrate, produced by gut microorganisms, play a critical role in energy metabolism and physiology of ruminants as well as in human health. In this study, the temporal effect of elevated butyrate concentrations on the transcriptome of the rumen epithelium was quantified via serial biopsy sampling using RNA-seq technology. The mean number of genes transcribed in the rumen epithelial transcriptome was 17,323.63 ± 277.20 (±SD; N = 24) while the core transcriptome consisted of 15,025 genes. Collectively, 80 genes were identified as being significantly impacted by butyrate infusion across all time points sampled. Maximal transcriptional effect of butyrate on the rumen epithelium was observed at the 72-h infusion when the abundance of 58 genes was altered. The initial reaction of the rumen epithelium to elevated exogenous butyrate may represent a stress response as Gene Ontology (GO) terms identified were predominantly related to responses to bacteria and biotic stimuli. An algorithm for the reconstruction of accurate cellular networks (ARACNE) inferred regulatory gene networks with 113,738 direct interactions in the butyrate-epithelium interactome using a combined cutoff of an error tolerance (ɛ = 0.10) and a stringent P-value threshold of mutual information (5.0 × 10(-11)). Several regulatory networks were controlled by transcription factors, such as CREBBP and TTF2, which were regulated by butyrate. Our findings provide insight into the regulation of butyrate transport and metabolism in the rumen epithelium, which will guide our future efforts in exploiting potential beneficial effect of butyrate in animal well-being and human health.
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