ArticleJournal of biomedicine & biotechnology2012
Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 101 citations in OpenAlex.
- Camel Milk in Skin Cancer Therapeutics: AnAnti-cancer agents in medicinal chemistry · 2026Article
- Bio fluid exosomes: promises, challenges, and future directions in translational medicine.Journal of translational medicine · 2025Review
- Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics.Cells · 2025Review
- An overview of probiotic camel milk as a nutritional beverage: Challenges and perspectives.Food science & nutrition · 2024Review
- Is camel's urine friend or enemy? Review of its role in human health or diseases.Open veterinary journal · 2023Review
- Ameliorative effects of camel milk and silymarin upon aflatoxin B1 induced hepatic injury in rats.Scientific reports · 2023Article
- Antibacterial, Antifungal, and Anticancer Effects of Camel Milk Exosomes: An In Vitro Study.Veterinary sciences · 2023Article
- Camels' biological fluids contained nanobodies: promising avenue in cancer therapy.Cancer cell international · 2022Review
- Prospective Role of Bioactive Molecules and Exosomes in the Therapeutic Potential of Camel Milk against Human Diseases: An Updated Perspective.Life (Basel, Switzerland) · 2022Review
- The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer.International journal of molecular sciences · 2022Review
- Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Camels, Camel Milk, and Camel Milk Product Situation in Kenya in Relation to the World.International journal of food science · 2022Review
- Research Development on Anti-Microbial and Antioxidant Properties of Camel Milk and Its Role as an Anti-Cancer and Anti-Hepatitis Agent.Antioxidants (Basel, Switzerland) · 2021Review
- Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma.Scientific reports · 2021Article
- Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-PPAR research · 2021Article
- More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer.International journal of molecular sciences · 2020Review
- Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Therapeutic Effect of Camel Milk and Its Exosomes on MCF7 Cells In Vitro and In Vivo.Integrative cancer therapies · 2018Article
- Potential antioxidant bioactive peptides from camel milk proteins.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few published studies have reported the use of crude camel milk in the treatment of stomach infections, tuberculosis and cancer. Yet, little research was conducted on the effect of camel milk on the apoptosis and oxidative stress associated with human cancer. The present study investigated the effect and the underlying mechanisms of camel milk on the proliferation of human cancer cells using an in vitro model of human hepatoma (HepG2) and human breast (MCF7) cancer cells. Our results showed that camel milk, but not bovine milk, significantly inhibited HepG2 and MCF7 cells proliferation through the activation of caspase-3 mRNA and activity levels, and the induction of death receptors in both cell lines. In addition, Camel milk enhanced the expression of oxidative stress markers, heme oxygenase-1 and reactive oxygen species production in both cells. Mechanistically, the increase in caspase-3 mRNA levels by camel milk was completely blocked by the transcriptional inhibitor, actinomycin D; implying that camel milk increased de novo RNA synthesis. Furthermore, Inhibition of the mitogen activated protein kinases differentially modulated the camel milk-induced caspase-3 mRNA levels. Taken together, camel milk inhibited HepG2 and MCF7 cells survival and proliferation through the activation of both the extrinsic and intrinsic apoptotic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.