ArticleSleep2012
Decoupling of sleepiness from sleep time and intensity during chronic sleep restriction: evidence for a role of the adenosine system.
Article in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine AProceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Review
- Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice.Frontiers in neuroscience · 2022Article
- Differential modulation of NREM sleep regulation and EEG topography by chronic sleep restriction in mice.Scientific reports · 2020Article
- Sleep deprivation alters the time course but not magnitude of locomotor sensitization to cocaine.Scientific reports · 2018Article
- Modeling the adenosine system as a modulator of cognitive performance and sleep patterns during sleep restriction and recovery.PLoS computational biology · 2017Article
- Effects of Sleep Deprivation on Spatial Learning and Memory in Juvenile and Young Adult Rats.Psychology & neuroscience · 2017Article
- Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome.Frontiers in neuroscience · 2017Article
- Leukocyte Expression of Type 1 and Type 2 Purinergic Receptors and Pro-Inflammatory Cytokines during Total Sleep Deprivation and/or Sleep Extension in Healthy Subjects.Frontiers in neuroscience · 2017Article
- Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome.Neuropharmacology · 2016Article
- Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.Psychopharmacology · 2016Review
- Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: A high density EEG investigation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
- From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy.Epilepsia · 2016Review
- A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction.PloS one · 2016Article
- Chronic sleep restriction induces long-lasting changes in adenosine and noradrenaline receptor density in the rat brain.Journal of sleep research · 2015Article
- Behavioral sleep-wake homeostasis and EEG delta power are decoupled by chronic sleep restriction in the rat.Sleep · 2015Article
- Article
- Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression.Neuroscience letters · 2014Article
- Effects of sleep fragmentation on sleep and markers of inflammation in mice.Comparative medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectiveSleep responses to chronic sleep restriction (CSR) might be very different from those observed after short-term total sleep deprivation. For example, after sleep restriction continues for several consecutive days, animals no longer express compensatory increases in daily sleep time and sleep intensity. However, it is unknown if these allostatic, or adaptive, sleep responses to CSR are paralleled by behavioral and neurochemical measures of sleepiness.
designThis study was designed to investigate CSR-induced changes in (1) sleep time and intensity as a measure of electrophysiological sleepiness, (2) sleep latency as a measure of behavioral sleepiness, and (3) brain adenosine A1 (A1R) and A2a receptor (A2aR) mRNA levels as a putative neurochemical correlate of sleepiness. SUBJECTS: Male Sprague-Dawley rats
interventionsA 5-day sleep restriction (SR) protocol consisting of 18-h sleep deprivation and 6-h sleep opportunity each day. MEASUREMENT AND
resultsUnlike the first SR day, rats did not sleep longer or deeper on days 2 through 5, even though they exhibited significant elevations of behavioral sleepiness throughout all 5 SR days. For all SR days and recovery day 1, A1R mRNA in the basal forebrain was maintained at elevated levels, whereas A2aR mRNA in the frontal cortex was maintained at reduced levels.
conclusionCSR LEADS TO A DECOUPLING OF SLEEPINESS FROM SLEEP TIME AND SLEEP INTENSITY, SUGGESTING THAT THERE ARE AT LEAST TWO DIFFERENT SLEEP REGULATORY SYSTEMS: one mediating sleepiness (homeostatic) and the other mediating sleep time/intensity (allostatic). The time course of changes observed in adenosine receptor mRNA levels suggests that the basal forebrain and cortical adenosine system might mediate sleepiness rather than sleep time or intensity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.