Evidence map›Paper›PMID 22654195›Full record

Trial reportSleep2012

A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea: the HomePAP study.

Carol L Rosen, Dennis Auckley, Ruth Benca, Nancy Foldvary-Schaefer, Conrad Iber, Vishesh Kapur, Michael Rueschman, Phyllis Zee, Susan Redline

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 169 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 11 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05382754 narecruitingnot on this mapstarted 2023, after this paper: background citation

Home Sleep Apnea Testing Compared to In-lab Polysomnography for the Evaluation of Obstructive Sleep Apnea in Children

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2023 to 2027Enrolled317ConditionsSleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep DisturbanceArmsHome sleep apnea test, In-lab polysomnography
NCT05516524 nacompletednot on this mapstarted 2022, after this paper: background citation

Home Sleep Apnea Testing for the Evaluation of Obstructive Sleep Apnea in Children Following Management With Adenotonsillectomy

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2022 to 2025Enrolled62ConditionsSleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep DisturbanceArmsHome sleep apnea test, PSG
3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 11 syntheses or guidelines pooled it, 361 citations in OpenAlex.

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  8. Treatment of Adult Obstructive Sleep Apnea With Positive Airway Pressure: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Pooled it
  9. Treatment of Adult Obstructive Sleep Apnea with Positive Airway Pressure: An American Academy of Sleep Medicine Clinical Practice Guideline.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Guideline
  10. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
    Guideline
  11. Pooled it
  12. What's leak got to do with it? Association of mask leak and positive airway pressure adherence from the homepap study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Trial
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  14. Comparison of clinical pathways for hypoglossal nerve stimulation management: in-laboratory titration polysomnography vs home-based efficacy sleep testing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Trial
  15. Dose-response relationship between positive airway pressure therapy and excessive daytime sleepiness: the HomePAP study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
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  18. Validation of the Withings Sleep Analyzer, an under-the-mattress device for the detection of moderate-severe sleep apnea syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Carol L RosenUniversity Hospitals-Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. carol.rosen@case.edu
Dennis Auckley
Ruth Benca
Nancy Foldvary-Schaefer
Conrad Iber
Vishesh Kapur
Michael Rueschman
Phyllis Zee
Susan Redline
Case Western Reserve University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USHennepin County Medical Center · USNorthwestern University · USUniversity Hospitals Case Medical Center · USUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesTo test the utility of an integrated clinical pathway for obstructive sleep apnea (OSA) diagnosis and continuous positive airway pressure (CPAP) treatment using portable monitoring devices.

designRandomized, open-label, parallel group, unblinded, multicenter clinical trial comparing home-based, unattended portable monitoring for diagnosis and autotitrating CPAP (autoPAP) compared with in-laboratory polysomnography (PSG) and CPAP titration.

settingSeven American Academy of Sleep Medicine (AASM) accredited sleep centers.

participantsConsecutive new referrals, age 18 yr or older with high probability of moderate to severe OSA (apnea-hypopnea index [AHI] ≥ 15) identified by clinical algorithm and Epworth Sleepiness Scale (ESS) score ≥ 12.

interventionsHome-based level 3 testing followed by 1 wk of autoPAP with a fixed pressure CPAP prescription based on the 90% pressure from autotitration of PAP therapy (autoPAP) device (HOME) compared with attended, in-laboratory studies (LAB). MEASUREMENTS: CPAP acceptance, time to treatment, adherence at 1 and 3 mo; changes in ESS, and functional outcomes.

resultsOf 373 participants, approximately one-half in each study arm remained eligible (AHI ≥ 15) to continue in the study. At 3 mo, PAP usage (nightly time at pressure) was 1 hr greater: 4.7 ± 2.1 hr (HOME) compared with 3.7 ± 2.4 hr (LAB). Adherence (percentage of night used ≥ 4 hr) was 12.6% higher: 62.8 ± 29.2% compared with 49.4 ± 36.1% in the HOME versus LAB. Acceptance of PAP therapy, titration pressures, effective titrations, time to treatment, and ESS score change did not differ between arms.

conclusionsA home-based strategy for diagnosis and treatment compared with in-laboratory PSG was not inferior in terms of acceptance, adherence, time to treatment, and functional improvements.

trial registrationhttp://www.ClinicalTrials.gov; Identifier: NCT: 00642486.

Indexed as

Continuous Positive Airway PressureFemaleHome Care ServicesHumansMaleMiddle AgedPatient CompliancePolysomnographySleep Apnea, ObstructiveTreatment OutcomeautotitrationdiagnosisOSAportable monitoringrandomized clinical trial

Identifiers

PMID22654195
PMCPMC3353048
OpenAlexW2170910182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.