ArticleJournal of biological physics2011
The role of spiking and bursting pacemakers in the neuronal control of breathing.
Article in Journal of biological physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
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- The Na+/K+-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure.PLoS computational biology · 2024Article
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- Complex oscillations in the Belousov-Zhabotinsky batch reaction with methylmalonic acid and manganese(ii).RSC advances · 2021Article
- Endogenous hydrogen sulfide maintains eupnea in an in situ arterially perfused preparation of rats.Communications biology · 2020Article
- Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum.Cell reports · 2020Article
- Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development.Respiratory physiology & neurobiology · 2019Review
- Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive.Frontiers in physiology · 2019Article
- Maturation of Breathing-Related Inhibitory Neurotransmission in the Medulla Oblongata of the Embryonic and Perinatal Zebra Finch (Taeniopygia guttata).Developmental neurobiology · 2018Article
- Different roles for inhibition in the rhythm-generating respiratory network.Journal of neurophysiology · 2017Article
- Relationship in Pacemaker Neurons Between the Long-Term Correlations of Membrane Voltage Fluctuations and the Corresponding Duration of the Inter-Spike Interval.The Journal of membrane biology · 2017Article
- Respiratory rhythm generation: triple oscillator hypothesis.F1000Research · 2017Review
- Neuronal Population Activity in Spinal Motor Circuits: Greater Than the Sum of Its Parts.Frontiers in neural circuits · 2017Review
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks.eLife · 2016Article
- Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network.eLife · 2016Article
- Modeling the effects of extracellular potassium on bursting properties in pre-Bötzinger complex neurons.Journal of computational neuroscience · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Breathing is controlled by a distributed network involving areas in the neocortex, cerebellum, pons, medulla, spinal cord, and various other subcortical regions. However, only one area seems to be essential and sufficient for generating the respiratory rhythm: the preBötzinger complex (preBötC). Lesioning this area abolishes breathing and following isolation in a brain slice the preBötC continues to generate different forms of respiratory activities. The use of slice preparations led to a thorough understanding of the cellular mechanisms that underlie the generation of inspiratory activity within this network. Two types of inward currents, the persistent sodium current (I(NaP)) and the calcium-activated non-specific cation current (I(CAN)), play important roles in respiratory rhythm generation. These currents give rise to autonomous pacemaker activity within respiratory neurons, leading to the generation of intrinsic spiking and bursting activity. These membrane properties amplify as well as activate synaptic mechanisms that are critical for the initiation and maintenance of inspiratory activity. In this review, we describe the dynamic interplay between synaptic and intrinsic membrane properties in the generation of the respiratory rhythm and we relate these mechanisms to rhythm generating networks involved in other behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.