Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2012
A novel cardiopulmonary exercise test protocol and criterion to determine maximal oxygen uptake in chronic heart failure.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01998256 (A Prospective, Patient Blinded, Cross-over Study of the Effect on Clinical Outcomes of AV Optimization in All Comer Ambulatory Patients With a Dual Chamber Pacemaker - The Role of Atrial Function and Interatrial Conduction Delay), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Patient Blinded, Cross-over Study of the Effect on Clinical Outcomes of AV Optimization in All Comer Ambulatory Patients With a Dual Chamber Pacemaker - The Role of Atrial Function and Interatrial Conduction Delay
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Running Assessed Maximal Oxygen Uptake Increases with Participant Classification Framework Tier in Overall Cross-Country Skiing Performance: A Systematic Review with Meta-regressions.Sports medicine - open · 2026Pooled it
- Pooled it
- Pooled it
- The Respiratory Compensation Point: Mechanisms and Relation to the Maximal Metabolic Steady State.Sports medicine (Auckland, N.Z.) · 2024Review
- A verification phase adds little value to the determination of maximum oxygen uptake in well-trained adults.European journal of applied physiology · 2024Article
- Exercise intensity prescription in cardiovascular rehabilitation: bridging the gap between best evidence and clinical practice.Frontiers in cardiovascular medicine · 2024Review
- Cardiopulmonary Exercise Testing: Methodology, Interpretation, and Role in Exercise Prescription for Cardiac Rehabilitation.US cardiology · 2024Review
- Is the Verification Phase a Suitable Criterion for the Determination of Maximum Oxygen Uptake in Patients with Heart Failure and Reduced Ejection Fraction? A Validation Study.International journal of environmental research and public health · 2023Article
- Efficacy of interval exercise training to improve vascular health in sedentary postmenopausal females.Physiological reports · 2022Article
- Identification of Non-Invasive Exercise Thresholds: Methods, Strategies, and an Online App.Sports medicine (Auckland, N.Z.) · 2022Review
- The Oxygen Uptake Plateau-A Critical Review of the Frequently Misunderstood Phenomenon.Sports medicine (Auckland, N.Z.) · 2021Review
- Utility of Verification Testing to Confirm Attainment of Maximal Oxygen Uptake in Unhealthy Participants: A Perspective Review.Sports (Basel, Switzerland) · 2021Review
- Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction.Frontiers in physiology · 2021Article
- Evaluating the suitability of supra-POAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Near-infrared Spectroscopy of Vastus Lateralis Muscle during Incremental Cycling Exercise in patients with Type 2 Diabetes.Physical therapy research · 2020Article
- Commentaries on Viewpoint: V̇oJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Reliability and Physiological Interpretation of Pulmonary Gas Exchange by "Circulatory Equivalents" in Chronic Heart Failure.Journal of the American Heart Association · 2018Article
- Measurement of a True [Formula: see text]OFrontiers in physiology · 2018Article
- The Maximal Oxygen Uptake Verification Phase: a Light at the End of the Tunnel?Sports medicine - open · 2017Review
- Interval exercise increases angiogenic cell function in postmenopausal women.BMJ open sport & exercise medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Cardiopulmonary exercise testing for peak oxygen uptake (Vo(2peak)) can evaluate prognosis in chronic heart failure (CHF) patients, with the peak respiratory exchange ratio (RER(peak)) commonly used to confirm maximal effort and maximal oxygen uptake (Vo(2max)). We determined the precision of RER(peak) in confirming Vo(2max), and whether a novel ramp-incremental (RI) step-exercise (SE) (RISE) test could better determine Vo(2max) in CHF. Male CHF patients (n = 24; NYHA class I-III) performed a symptom-limited RISE-95 cycle ergometer test in the format: RI (4-18 W/min; ∼10 min); 5 min recovery (10 W); SE (95% peak RI work rate). Patients (n = 18) then performed RISE-95 tests using slow (3-8 W/min; ∼15 min) and fast (10-30 W/min; ∼6 min) ramp rates. Pulmonary gas exchange was measured breath-by-breath. Vo(2peak) was compared within patients by unpaired t-test of the highest 12 breaths during RI and SE phases to confirm Vo(2max) and its 95% confidence limits (CI(95)). RER(peak) was significantly influenced by ramp rate (fast, medium, slow: 1.21 ± 0.1 vs. 1.15 ± 0.1 vs. 1.09 ± 0.1; P = 0.001), unlike Vo(2peak) (mean n = 18; 14.4 ± 2.6 ml·kg(-1)·min(-1); P = 0.476). Group Vo(2peak) was similar between RI and SE (n = 24; 14.5 ± 3.0 vs. 14.7 ± 3.1 ml·kg(-1)·min(-1); P = 0.407); however, within-subject comparisons confirmed Vo(2max) in only 14 of 24 patients (CI(95) for Vo(2max) estimation averaged 1.4 ± 0.8 ml·kg(-1)·min(-1)). The RER(peak) in CHF was significantly influenced by ramp rate, suggesting its use to determine maximal effort and Vo(2max) be abandoned. In contrast, the RISE-95 test had high precision for Vo(2max) confirmation with patient-specific CI(95) (without secondary criteria), and showed that Vo(2max) is commonly underestimated in CHF. The RISE-95 test was well tolerated by CHF patients, supporting its use for Vo(2max) confirmation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.